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Logo of procrsmedFormerly medchtJournal of the Royal Society of MedicineProceedings of the Royal Society of Medicine
Proc R Soc Med. 1977 February; 70(2): 89–90.
PMCID: PMC1542933

Current status of vitamin D metabolism.


In summary one can record that the biochemist has discovered a beautiful metabolic pathway for vitamin D which is probably as yet incomplete. Subsequently the medicinal chemist has provided numerous synthetic analogues. However, delays in the diagnosis and treatment of vitamin D disorders, due to lack of specific assays and inadequate supplies of therapeutic metabolites, still unfortunately exist. It is hoped that these problems will be rectified as soon as more plentiful supplies of the appropriate metabolites are available.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bhattacharyya MH, DeLuca HF. The regulation of rat liver calciferol-25-hydroxylase. J Biol Chem. 1973 May 10;248(9):2969–2973. [PubMed]
  • Blunt JW, DeLuca HF, Schnoes HK. 25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3. Biochemistry. 1968 Oct;7(10):3317–3322. [PubMed]
  • Brickman AS, Coburn JW, Norman AW. Action of 1,25-dihydroxycholecalciferol, a potent, kidney-produced metabolite of vitamin D, in uremic man. N Engl J Med. 1972 Nov 2;287(18):891–895. [PubMed]
  • Brumbaugh PF, Haussler DH, Bursac KM, Haussler MR. Filter assay for 1alpha, 25-dihydroxyvitamin D3. Utilization of the hormone's target tissue chromatin receptor. Biochemistry. 1974 Sep 24;13(20):4091–4097. [PubMed]
  • Fraser DR, Kodicek E. Unique biosynthesis by kidney of a biological active vitamin D metabolite. Nature. 1970 Nov 21;228(5273):764–766. [PubMed]
  • Ghazarian JG, DeLuca HF. 25-Hydroxycholecalciferol-1-hydroxylase: a specific requirement for NADPH and a hemoprotein component in chick kidney mitochondria. Arch Biochem Biophys. 1974 Jan;160(1):63–72. [PubMed]
  • Haddad JG, Chyu KJ. Competitive protein-binding radioassay for 25-hydroxycholecalciferol. J Clin Endocrinol Metab. 1971 Dec;33(6):992–995. [PubMed]
  • Lund J, DeLuca HF. Biologically active metabolite of vitamin D3 from bone, liver, and blood serum. J Lipid Res. 1966 Nov;7(6):739–744. [PubMed]
  • McLaughlin M, Raggatt PR, Fairney A, Brown DJ, Lester E, Wills MR. Seasonal variations in serum 25-hydroxycholecalciferol in healthy people. Lancet. 1974 Mar 30;1(7857):536–538. [PubMed]
  • Zull JE, Czarnowska-Misztal E, Deluca HF. Actinomycin D Inhibition of Vitamin D Action. Science. 1965 Jul 9;149(3680):182–184. [PubMed]

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