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Logo of procrsmedFormerly medchtJournal of the Royal Society of MedicineProceedings of the Royal Society of Medicine
Proc R Soc Med. 1977; 70(Suppl 1): 2–3.
PMCID: PMC1542865

Therapy for deep mycoses: an introduction.


A classification of mycoses, depending upon the depth of penetration of the organism is discussed, as is the need to distinguish the true from the 'pseudo' mycoses. The development of antifungal agents is described from the first antibiotics to amphotericin B and 5-fluorocytosine. Attention is particularly focussed on the question of safety and effectiveness. Finally, it is stressed that successful antifungal treatment must depend upon determination of the exact pathological status of the patient and examples are given which relate to such clinical assessments.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • GENTLES JC. Experimental ringworm in guinea pigs: oral treatment with griseofulvin. Nature. 1958 Aug 16;182(4633):476–477. [PubMed]
  • Krick JA, Remington JS. Editoral: Treatment of fungal infections. Arch Intern Med. 1975 Feb;135(2):344–346. [PubMed]
  • Medoff G, Kobayashi GS. Amphotericin B. Old drug, new therapy.?2110. JAMA. 1975 May 12;232(6):619–620. [PubMed]
  • Oxford AE, Raistrick H, Simonart P. Studies in the biochemistry of micro-organisms: Griseofulvin, C(17)H(17)O(6)Cl, a metabolic product of Penicillium griseo-fulvum Dierckx. Biochem J. 1939 Feb;33(2):240–248. [PubMed]

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