Search tips
Search criteria 


Logo of procrsmedFormerly medchtJournal of the Royal Society of MedicineProceedings of the Royal Society of Medicine
Proc R Soc Med. 1977; 70(Suppl 6): 4–10.
PMCID: PMC1542809

Comparative Studies of Gastric Ulcerogenesis by Non-steroid Anti-inflammatory Drugs

Effects of Fenclofenac

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.6M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Ackerman SH. Editorial: Restraint ulceration as an experimental disease model. Psychosom Med. 1975 Jan-Feb;37(1):4–7. [PubMed]
  • Atkinson DC, Leach EC. Anti-inflammatory and related properties of 2-(2,4-dichlorophenoxy)phenylacetic acid (fenclofenac). Agents Actions. 1976 Sep;6(5):657–666. [PubMed]
  • Beeken WL. Effect of salicylates on gastrointestinal protein loss in normal subjects. Gastroenterology. 1967 Dec;53(6):894–899. [PubMed]
  • Bowen JC, Fleming WH. A prospective study of stress ulceration in Vietnam. South Med J. 1974 Feb;67(2):156–160. [PubMed]
  • Brune K. How aspirin might work: a pharmacokinetic approach. Agents Actions. 1974 Oct;4(4):230–232. [PubMed]
  • Brune K, Graf P, Rainsford KD. A pharmacokinetic approach to the understanding of therapeutic effects and side effects of salicylates. Agents Actions Suppl. 1977;(1):9–26. [PubMed]
  • Brune K, Schweitzer A, Eckert H. Parietal cells of the stomach trap salicylates during absorption. Biochem Pharmacol. 1977 Sep 15;26(18):1735–1740. [PubMed]
  • Bullock GR, Delaney VB, Sawyer BC, Slater TF. Biochemical and structural changes in rat liver resulting from the parenteral administration of a large dose of sodium salicylate. Biochem Pharmacol. 1970 Jan;19(1):245–253. [PubMed]
  • Clarke James S, Coulson Walter F, Guth Paul H, Gray Robert K, Schwabe Arthur D, Ashley Franklin L, Batzdorf Ulrich. Gastroduodenal Stress Ulcers. Calif Med. 1972 Jan;116(1):32–46. [PMC free article]
  • Cooke AR. Drugs and gastric damage. Drugs. 1976;11(1):36–44. [PubMed]
  • DiPasquale G, Welaj P. Letter: Ulcerogenic potential of indomethacin in arthritic and non-arthritic rats. J Pharm Pharmacol. 1973 Oct;25(10):831–832. [PubMed]
  • Graf P, Glatt M, Brune K. Acidic nonsteroid anti-inflammatory drugs accumulating in inflamed tissue. Experientia. 1975 Aug 15;31(8):951–953. [PubMed]
  • Kawashima K, Jerzy Glass GB. Alcohol injury to gastric mucosa in mice and its potentiation by stress. Am J Dig Dis. 1975 Feb;20(2):162–172. [PubMed]
  • Kuiper DH, Overholt BF, Fall DJ, Pollard HM. Gastroscopic findings and fecal blood loss following aspirin administration. Am J Dig Dis. 1969 Nov;14(11):761–769. [PubMed]
  • Menassé-Gdynia R, Krupp P. Quantitative measurement of gastrointestinal bleeding in rats: the effect of nonsteroidal anti-inflammatory drugs. Toxicol Appl Pharmacol. 1974 Sep;29(3):389–396. [PubMed]
  • Menguy R. Acute gastric mucosal bleeding. Annu Rev Med. 1972;23:297–312. [PubMed]
  • Morton DM, Chatfield DH. The effects of adjuvant-induced arthritis on the liver metabolism of drugs in rats. Biochem Pharmacol. 1970 Feb;19(2):473–481. [PubMed]
  • Rainsford KD, Brune K. Role of the parietal cell in gastric damage induced by aspirin and related drugs: implications for safer therapy. Med J Aust. 1976 Jun 5;1(23):881–883. [PubMed]
  • Rainsford KD, Watkins J, Smith MJ. Aspirin and mucus. J Pharm Pharmacol. 1968 Dec;20(12):941–943. [PubMed]
  • Rainsford KD, Whitehouse MW. Gastric irritancy of aspirin and its congeners: anti-inflammatory activity without this side-effect. J Pharm Pharmacol. 1976 Jul;28(7):599–601. [PubMed]
  • Sofia RD, Diamantis W, Ludwig BJ. Comparative anti-inflammatory, analgesic, and antipyretic activities of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one and 5-chlorosalicylic acid in rats. J Pharm Sci. 1975 Aug;64(8):1321–1324. [PubMed]
  • Stephens FO, Lawrenson KB. 51Cr Excretion in bile. Lancet. 1969 Jan 18;1(7586):158–159. [PubMed]
  • Sun DC, Roth SH, Mitchell CS, Englund DW. Upper gastrointestinal disease in rheumatoid arthritis. Am J Dig Dis. 1974 May;19(5):405–410. [PubMed]
  • Whitehouse MW, Beck FJ. Impaired drug metabolism in rats with adjuvant-induced arthritis: a brief review. Drug Metab Dispos. 1973 Jan-Feb;1(1):251–255. [PubMed]

Articles from Proceedings of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press