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Logo of procrsmedFormerly medchtJournal of the Royal Society of MedicineProceedings of the Royal Society of Medicine
Proc R Soc Med. 1977; 70(Suppl 7): 32–34.
PMCID: PMC1542774

Mechanism of action of aspirin in inflammation.

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Selected References

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  • Bonta IL, Bult H, Vincent JE, Zijlstra FJ. Acute anti-inflammatory effects of aspirin and dexamethasone in rats deprived of endogenous prostaglandin precursors. J Pharm Pharmacol. 1977 Jan;29(1):1–7. [PubMed]
  • Bray MA, Gordon D. Effects of anti-inflammatory drugs on macrophage prostaglandin biosynthesis [proceedings]. Br J Pharmacol. 1976 Jul;57(3):466P–467P. [PMC free article] [PubMed]
  • Bray MA, Gordon D, Morley J. Proceedings: Role of prostaglandins in reactions of cellular immunity. Br J Pharmacol. 1974 Nov;52(3):453P–453P. [PMC free article] [PubMed]
  • Brocklehurst WE. Role of kinins and prostaglandins in inflammation. Proc R Soc Med. 1971 Jan;64(1):4–6. [PMC free article] [PubMed]
  • Cashin CH, Dawson W, Kitchen EA. The pharmacology of benoxaprofen (2-[4-chlorophenyl]-alpha-methyl-5-benzoxazole acetic acid), LRCL 3794, a new compound with antiinflammatory activity apparently unrelated to inhibition of prostaglandin synthesis. J Pharm Pharmacol. 1977 Jun;29(6):330–336. [PubMed]
  • Crout JE, Hepburn B, Ritts RE., Jr Suppression of lymphocyte transformation after aspirin ingestion. N Engl J Med. 1975 Jan 30;292(5):221–223. [PubMed]
  • Waterfield MD, Prahl JW, Hood LE, Kindt TJ, Krause RM. Restricted structural heterogeneity in antibodies: might different heavy chains have a common light chain? Nat New Biol. 1972 Dec 13;240(102):215–217. [PubMed]
  • Ferreira SH, Moncada S, Vane JR. Indomethacin and aspirin abolish prostaglandin release from the spleen. Nat New Biol. 1971 Jun 23;231(25):237–239. [PubMed]
  • Gordon D, Bray MA, Morley J. Control of lymphokine secretion by prostaglandins. Nature. 1976 Jul 29;262(5567):401–402. [PubMed]
  • Harris M, Jenkins MV, Bennett A, Wills MR. Prostaglandin production and bone resorption by dental cysts. Nature. 1973 Sep 28;245(5422):213–215. [PubMed]
  • Kantrowitz F, Robinson DR, McGuire MB, Levine L. Corticosteroids inhibit prostaglandin production by rheumatiod synovia. Nature. 1975 Dec 25;258(5537):737–739. [PubMed]
  • Kuehl FA, Jr, Humes JL, Egan RW, Ham EA, Beveridge GC, Van Arman CG. Role of prostaglandin endoperoxide PGG2 in inflammatory processes. Nature. 1977 Jan 13;265(5590):170–173. [PubMed]
  • Mills JA. Nonsteroidal anti-inflammatory drugs (first of two parts). N Engl J Med. 1974 Apr 4;290(14):781–784. [PubMed]
  • Moncada S, Ferreira SH, Vane JR. Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint. Eur J Pharmacol. 1975 Apr;31(2):250–260. [PubMed]
  • Opelz G, Terasaki PI, Hirata AA. Suppression of lymphocyte transformation by aspirin. Lancet. 1973 Sep 1;2(7827):478–480. [PubMed]
  • Panush RS, Anthony CR. Effects of acetylsalicylic acid on normal human peripheral blood lymphocytes. Inhibition of mitogen- and antigen-stimulated incorporation of tritiated thymidine. Clin Exp Immunol. 1976 Jan;23(1):114–125. [PubMed]
  • Smith JB, Willis AL. Aspirin selectively inhibits prostaglandin production in human platelets. Nat New Biol. 1971 Jun 23;231(25):235–237. [PubMed]
  • Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. [PubMed]
  • Williams TJ, Lewis GP. Proceedings: The pro-inflammatory activity of E-, A-, D- and F-type prostaglandins and analogues 16, 16-dimethyl-PGE2 and (15S)-15-methyl-PGE2 in rabbit skin; the relationship between potentiation of plasma exudation and local blood flow changes. Br J Pharmacol. 1976 Mar;56(3):341P–342P. [PMC free article] [PubMed]

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