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Arthritis Res. 2002; 4(6): 360–371.
Published online Sep 25, 2002.
PMCID: PMC153845
Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome
Thomas Dörnercorresponding author1 and Peter E Lipsky2
1Department of Medicine, Rheumatology and Clinical Immunology, University Hospital Charité, Berlin, Germany
2National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
corresponding authorCorresponding author.
Thomas Dörner: thomas.doemer/at/charite.de
Received July 22, 2002; Revised September 5, 2002; Accepted September 16, 2002.
Abstract
Primary Sjögren's syndrome (pSS) is an autoimmune disorder characterized by specific pathologic features and the production of typical autoantibodies. In addition, characteristic changes in the distribution of peripheral B cell subsets and differences in use of immunoglobulin variable-region genes are also features of pSS. Comparison of B cells from the blood and parotid gland of patients with pSS with those of normal donors suggests that there is a depletion of memory B cells from the peripheral blood and an accumulation or retention of these antigen-experienced B cells in the parotids. Because disordered selection leads to considerable differences in the B cell repertoire in these patients, the delineation of its nature should provide important further clues to the pathogenesis of this autoimmune inflammatory disorder.
Keywords: autoimmunity, B cells, IgV gene usage, lymphocytes, Sjögren's syndrome
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