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Targets for regulation by Leu3p-α-isopropylmalate in S. cerevisiae

First category: established targets
    LEU1/YGL009cIsopropylmalate isomerase7, 36
    LEU2/YCL018wβ-Isopropylmalate dehydrogenase7, 17, 36
    LEU4/YNL104cα-Isopropylmalate synthase I36, 52, 83
    ILV2/YMR108wAcetohydroxyacid synthase36
    ILV5/YLR355cAcetohydroxyacid reductoisomerase36
    BAP2/YBR068cBranched-chain amino acid permease77
    GDH1/YOR375cGlutamate dehydrogenase (NADP+)51
Second category: potential targetsa
    BAT1/YHR208wBranched-chain amino acid aminotransferase
    GAP1/YKR039wGeneral amino acid permease
    OAC1/YKL120wMitochondrial oxaloacetate, sulfate carrier
    MAE1/YKL029cMitochondrial malic enzyme
    LEU9/YOR108wα-Isopropylmalate synthase II
aThe first four of these genes meet two criteria: first, they rank very high in a genome-wide Leu3p binding-occupancy analysis (see text); second, they show diminished expression, as determined by a DNA microarray experiment, in cells whose genetic background allows only very little accumulation of α-isopropylmalate compared to cells whose genetic background allows strong accumulation of the coactivator (see text). The fifth gene (LEU9) meets only the first criterion.