Regions of interest along the primary structure of Leu3p of S. cerevisiae.aDNA binding region, residues 37 to 67, containing the cysteine motif for Zn(II)2Cys6 cluster formation;bMHR, residues 300 to 380;cthree clusters of residues (604 to 611, 643 to 664, and 738 to 741) potentially involved in activation domain masking;dregion dispensable for all known functions, residues 774 to 854;etranscriptional activation domain, residues 857 to 875; N, N terminus; C, C terminus. Note that the 11 C-terminal residues (residues 876 to 886), while not needed for the activation function, are essential for the masking process. See the text for further details.
Articles from Microbiology and Molecular Biology Reviews : MMBR are provided here courtesy of
American Society for Microbiology (ASM)