1. Weaver MF, Jarvis MAE, Schnoll SH. Role of the primary care physician in problems of substance abuse. Arch Intern Med. 1999;159:913–24. [PubMed] 2. Fiellin DA, Reid MC, O'Connor PG. Screening for alcohol problems in primary care: a systematic review. Arch Intern Med. 2000;160:1977–89. [PubMed]
4. American Psychiatric Association Committee on Nomenclature and Statistics. Diagnostic and Statistical Manual of Mental Disorders. 4th Ed. Washington, DC: American Psychiatric Association; 2000. Text Revision.
5. Potenza MN, Kosten TR, Rounsaville BJ. Pathological gambling. JAMA. 2001;286:141–4. [PubMed] 6. Shaffer HJ, Hall MN, Vander Bilt J. Estimating the prevalence of disordered gambling behavior in the United States and Canada: a research synthesis. Am J Public Health. 1999;89:1369–76. [PubMed] 7. Shaffer HJ, Hall MN. Updating and refining prevalence estimates of disordered gambling behavior in the United States and Canada. Can J Public Health. 2001;92:168–72. [PubMed] 8. Welte J, Barnes G, Wieczorek W, Tidwell M-C, Parker J. Alcohol and gambling pathology among U.S. adults: prevalence, demographic patterns and comorbidity. J Stud Alcohol. 2001;62:706–12. [PubMed] 9. Pasternak AV, Fleming MF. Prevalence of gambling disorders in a primary care setting. Arch Fam Med. 1999;8:515–20. [PubMed] 10. Gupta R, Derevensky JL. Adolescents with gambling problems: from research to treatment. J Gambl Stud. 2000;16:315–42. [PubMed] 11. Cunningham-Williams RM, Cottler LB, Compton WM, III, Spitznagel EL. Taking chances: problem gamblers and mental health disorders—results from the St. Louis Epidemiologic Catchment Area Study. Am J Public Health. 1998;88:1093–6. [PubMed] 12. Cunningham-Williams RM, Cottler LB. The epidemiology of pathological gambling. Semin Clin Neuropsychiatry. 2001;6:155–66. [PubMed] 13. Hollander E, Wong CM. Obsessive-compulsive spectrum disorders. J Clin Psychiatry. 1995;56(suppl 4):3–6. [PubMed] 14. Blanco C, Moreyra P, Nunes EV, Saiz-Ruiz J, Ibanez A. Pathological gambling: addiction or obsession? Semin Clin Neuropsychiatry. 2001;6:167–76. [PubMed] 15. Blaszczynski A. Pathological gambling and obsessive-compulsive spectrum disorders. Psychol Rep. 1999;84:107–13. [PubMed]
16. Hollander E, Stein DJ, Kwon JH, et al. Psychosocial function and economic costs of obsessive-compulsive disorder. CNS Spectrums. 1997;2:16–25.
17. Bienvenu OJ, Samuels JF, Riddle MA, et al. The relationship of obsessive-compulsive disorder to possible spectrum disorders: results from a family study. Biol Psychiatry. 2000;48:287–93. [PubMed] 18. Volkow ND, Fowler JS. Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb Cortex. 2000;10:318–25. [PubMed] 19. Maddux JF, Desmond DP. Addiction or dependence. Addiction. 2000;95:661–5. [PubMed] 20. Holden C. “Behavioral” addictions: do they exist. Science. 2001;294:980–2. [PubMed]
21. O'Brien CP. Principles of the pharmacotherapy of substance use disorders. In: Nestler EJ, Charney DS, Bunney BS, editors. Neurobiology of Mental Illness. New York: Oxford Press; 1999. pp. 627–38.
22. Potenza MN, Wilber MK. Neuroimaging studies of pathological gambling and substance dependence. Psychiatr Times. 2001;18:58–64.
23. Potenza MN, Charney DS. Pathological gambling: a current perspective. Semin Clin Neuropsychiatry. 2001;6:153–4. [PubMed] 25. Slutske WS, Eisen S, True WR, Lyons MJ, Goldberg J, Tsuang M. Common genetic vulnerability for pathological gambling and alcohol dependence in men. Arch Gen Psychiatry. 2000;57:666–74. [PubMed]
26. Hodgins DC, Wynne H, Makarchuk K. Pathways to recovery from gambling problems: follow-up from a general population survey. J Gambl Stud. 1999;15:93–104.
27. Hodgins DC, El-Guebaly N. Natural and treatment-assisted recovery from gambling problems: a comparison of resolved and active gamblers. Addiction. 2000;95:777–89. [PubMed] 28. Hodgins DC. Processes of changing gambling behavior. Addict Behav. 2001;26:121–8. [PubMed] 29. Sobell LC, Ellingstad TP, Sobell MB. Natural recovery from alcohol and drug problems: methodological review of the research with suggestions for future directions. Addiction. 2000;95:749–64. [PubMed] 30. Randall CL, Robert JS, Del Boca FK, Carroll KM, Connor GJ, Mattson ME. Telescoping of landmark events associated with drinking: a gender comparison. J Stud Alcohol. 1999;60:252–60. [PubMed] 31. Griffin ML, Weiss RD, Mirin SM, Lange U. A comparison of male and female cocaine abusers. Arch Gen Psychiatry. 1989;46:122–6. [PubMed] 32. Westermeyer J, Boedicker AE. Course, severity, and treatment of substance abuse among men versus women. Am J Drug Alcohol Abuse. 2000;26:523–35. [PubMed] 33. Potenza MN, Steinberg MA, McLaughlin SD, Wu R, Rounsaville BJ, O'Malley SS. Gender-related differences in the characteristics of problem gamblers using a gambling helpline. Am J Psychiatry. 2001;158:1500–5. [PubMed] 34. Taveres H, Zilberman ML, Beites FJ, Gentil V. Gender differences in gambling progression. J Gambl Stud. 2001;17:151–60. [PubMed] 35. Potenza MN, Steinberg MA, McLaughlin SD, Wu R, Rounsaville BJ, O'Malley SO. Illegal behaviors in problem gambling: analysis of data from a gambling helpline. J Am Acad Psychiatry Law. 2000;28:389–403. [PubMed] 36. Lesieur HR. Types, lotteries, and substance abuse among problem gamblers: commentary on “Illegal behaviors in problem gambling: analysis of data from a gambling helpline.” J Am Acad Psychiatry Law. 2000;28:404–7. [PubMed] 37. Johnson BA, Roache JD, Javors MA, et al. Ondansetron for reduction of drinking among biologically predisposed alcoholic patients. JAMA. 2000;284:963–71. [PubMed] 38. Crockford DN, el-Guebaly N. Psychiatric comorbidity in pathological gambling: a critical review. Can J Psychiatry. 1998;43:43–50. [PubMed]
39. Steinberg MA, Kosten TA, Rounsaville BJ. Cocaine abuse and pathological gambling. Am J Addict. 1992;1:121–32.
40. Hall GW, Carriero NJ, Takushi RY, Montoya ID, Preston KL, Gorelick DA. Pathological gambling among cocaine-dependent outpatients. Am J Psychiatry. 2000;157:1127–33. [PubMed] 41. Spunt B, Lesieur H, Hunt D, Cahill L. Gambling among methadone patients. Int J Addict. 1995;30:929–62. [PubMed] 42. McCormick RA, Russo AM, Ramirez LF, Taber JI. Affective disorders among pathological gamblers seeking treatment. Am J Psychiatry. 1984;141:215–8. [PubMed] 43. Lesieur HR, Blume SB. Evaluation of patients treated for pathological gambling in a combined alcohol, substance abuse and pathological gambling treatment unit using the Addiction Severity Index. Br J Addict. 1991;86:1017–28. [PubMed] 44. Smart RG, Ferris J. Alcohol, drugs and gambling in the Ontario adult population, 1994. Can J Psychiatry. 1996;41:36–45. [PubMed] 45. Feigelman W, Wallisch LS, Lesieur HR. Problem gamblers, problem substance users, and dual-problem individuals: an epidemiological study. Am J Public Health. 1998;88:467–70. [PubMed] 46. Eisen SA, Slutske WS, Lyons MJ, et al. The genetics of pathological gambling. Semin Clin Neuropsychiatry. 2001;6:195–204. [PubMed] 47. Slutske WS, Eisen S, Xian H, et al. A twin study of the association between pathological gambling and antisocial personality disorder. J Abnorm Psychol. 2001;110:297–308. [PubMed] 48. Potenza MN. The neurobiology of pathological gambling. Semin Clin Neuropsychiatry. 2001;6:217–26. [PubMed] 49. Breiter HC, Gollub RL, Weisskopf RM, et al. Acute effects of cocaine on human brain activity and emotion. Neuron. 1997;19:591–611. [PubMed] 50. Breiter HC, Aharon I, Kahneman D, Dale A, Shizgal P. Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Neuron. 2001;30:619–39. [PubMed] 51. Wexler BE, Gottschalk CH, Fulbright RF, et al. Functional magnetic resonance imaging of cocaine craving. Am J Psychiatry. 2001;158:86–95. [PubMed] 52. Childress AR, Mozely PD, McElgin W, Fitzgerald J, Reivich M, O'Brien CP. Limbic activation during cue-induced cocaine craving. Am J Psychiatry. 1999;156:11–8. [PMC free article] [PubMed]
53. National Research Council. Pathological Gambling: A Critical Review. Washington, DC: National Academy Press; 1999.
54. Babor TF, Higgins-Biddle JC. Alcohol screening and brief intervention: dissemination strategies for medical practice and public health. Addiction. 2000;95:677–86. [PubMed]
55. National Institute on Drug Abuse. The economic costs of alcohol and drug abuse in the United States. Rockville, Md: National Institute on Drug Abuse; 1998.
56. Potenza MN. A perspective on future directions in the prevention, treatment and research of pathological gambling. Psychiatr Ann. 2002;32:203–7.
57. McLellan AT, Lewis DC, O'Brien CP, Kleber HD. Drug dependence, a chronic medical illness. JAMA. 2000;284:1689–95. [PubMed] 58. Cunningham-Williams RM, Cottler LB, Compton WM, Spitznagel EL, Ben-Abdallah A. Problem gambling and comorbid psychiatric and substance use disordersamong drug users recruited from drug treatment settings and the community. J Gambl Stud. 2000;16:347–76. [PubMed] 59. Eisen SA, Lin N, Lyons MJ, et al. Familial influences on gambling behavior: an analysis of 3359 twin pairs. Addiction. 1998;93:1375–84. [PubMed] 60. Korn DA, Shaffer HJ. Gambling and the health of the public: adopting a public health perspective. J Gambl Stud. 1999;15:289–365. [PubMed]
61. Rosecrance J. Gambling without Guilt: The Legitimization of an American Pastime. Pacific Grove, Calif: Brooks/Cole Publishing Company; 1988.
62. Bechara A, Damasio H, Damasio HR. Emotion, decision making and the orbitofrontal cortex. Cereb Cortex. 2000;10:295–307. [PubMed] 63. Bechara A. Neurobiology of decision-making: risk and reward. Semin Clin Neuropsychiatry. 2001;6:205–16. [PubMed]
64. Chambers RA, Potenza MN. Neurodevelopment, impulsivity and adolescent gambling. J Gambl Stud. In press.
65. DeCaria CM, Hollander E, Grossman R, Wong CM, Mosovich SA, Cherkasky S. Diagnosis, neurobiology, and treatment of pathological gambling. J Clin Psychiatry. 1996;57(suppl 8):80–3. [PubMed] 66. Phillips DP, Welty WR, Smith MM. Elevated suicide levels associated with legalized gambling. Suicide Life Threat Behav. 1997;27:373–8. [PubMed] 67. Holmes EK, Mateczun JM, Lall R, Wilcove GL. Pilot study of suicide risk factors among personnel in the United States Marine Corps (Pacific Forces) Psychol Rep. 1998;83:3–11. [PubMed] 68. Shaffer HJ, Vander Bilt J, Hall MN. Gambling, drinking, smoking and other health risk activities among casino employees. Am J Ind Med. 1999;36:365–78. [PubMed] 69. Jason DR, Taff ML, Boglioli LR. Casino-related deaths in Atlantic City, New Jersey 1982–1986. Am J Forensic Med Pathol. 1990;11:112–23. [PubMed] 70. Harvard Medical School Division on Addictions. Gambling Mortality. The WAGER. 2000;5(41):1–3. http://www.thewager.org. Accessed October 18, 2000. 71. Valenzuela TD, Roe DJ, Nichol G, Clark LL, Spaite DW, Hardman RG. Outcomes of rapid defibrillation by security officers after cardiac arrest in casinos. N Engl J Med. 2000;343:1206–9. [PubMed] 72. Meyer G, Hauffa BP, Schedlowski M, Pawluk C, Stadler MA, Exton MS. Casino gambling increases heart rate and salivary cortisol in regular gamblers. Biol Psychiatry. 2000;48:948–53. [PubMed]
73. Baker GJ, Suchday S, Krantz DS. Heart disease/attack. In: Fink G, editor. Encyclopedia of Stress. New York: Academic Press; 2000. pp. 326–33.
74. Zipes DP. Sudden cardiac death. In: Bennett JC, Plum F, editors. Cecil Textbook of Medicine. Philadelphia: Harcourt Brace and Co.; 1996. pp. 253–56.
75. Shinohara K, Yanagisawa A, Kagota Y, et al. Physiological changes in Pachinko players; beta-endorphin, catecholamines, immune system substances and heart rate. Appl Human Sci. 1999;18:37–42. [PubMed] 76. Roy A, Adinoff B, Roehrich L, et al. Pathological gambling: a psychobiological study. Arch Gen Psychiatry. 1988;45:369–73. [PubMed] 77. Roy A, De Jong J, Linnoila M. Extraversion in pathological gamblers. Correlates with indexes of noradrenergic function. Arch Gen Psychiatry. 1989;46:679–81. [PubMed] 78. Schmitt LH, Harrison GA, Spargo RM. Variation in epinephrine and cortisol excretion rates associated with behavior in an Australian aboriginal community. Am J Phys Anthropol. 1998;106:249–53. [PubMed] 79. Stinchfield R, Winters KC. Outcome of Minnesota's gambling treatment programs. J Gambl Stud. 2001;17:217–46. [PubMed] 80. Stewart RM, Brown RI. An outcome study of Gamblers Anonymous. Br J Psychiatry. 1988;152:284–8. [PubMed] 81. Kownacki RJ, Shadish WR. Does Alcoholics Anonymous work. The results from a meta-analysis of controlled experiments. Subst Use Misuse. 1999;34:1897–916. [PubMed] 82. Petry N, Roll JM. A behavioral approach to understanding and treating pathological gambling. Semin Clin Neuropsychiatry. 2001;6:177–83. [PubMed] 83. McConaghy N, Armstrong MS, Blaszczynski A, Allcock C. Controlled comparison of aversive therapy and imaginal desensitization in compulsive gambling. Br J Psychiatry. 1983;142:366–72. [PubMed] 84. Sylvain C, Ladouceur R, Boisvert J-M. Cognitive and behavioral treatment of pathological gambling: a controlled study. J Consult Clin Psychol. 1997;65:727–32. [PubMed] 85. Ladouceur R, Sylvain C, Boutin C, et al. Cognitive treatment of pathological gambling. J Nerv Ment Dis. 2001;189:774–80. [PubMed] 86. Hodgins DC, Currie SR, el-Guebaly N. Motivational enhancement and self-help treatments for problem gambling. J Clin Consult Psychol. 2001;69:50–7. [PubMed] 87. Kim SW, Grant J. The psychopharmacology of pathological gambling. Semin Clin Neuropsychiatry. 2001;6:184–94. [PubMed]
88. Grant JE, Kim SW, Potenza MN. Advances in the pharmacological treatment of pathological gambling disorder. J Gambl Stud. In press.
89. Hollander E, De Caria CM, Finkell JN, Begaz T, Wong CM, Cartwright C. A randomized double-blind fluvoxamine/placebo crossover trial in pathological gambling. Biol Psychiatry. 2000;47:813–7. [PubMed]
90. Kim SW, Grant JE, Adson DE, Shin YC, Zaninelli R. A double-blind, placebo-controlled study of the efficacy and safety of paroxetine in the treatment of pathological gambling disorder. J Clin Psychiatry. In press.
91. Kim SW, Grant JE, Adson DE, Shin YC. Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling. Biol Psychiatry. 2001;49:914–21. [PubMed]
92. Hollander E, Pallanti S, Rossi NB, Sood E, Buchsbaum M. Sustained release lithium/placebo treatment response and FDG-PET imaging of wagering in bipolar spectrum pathological gamblers. Presented at the American College of Neuropsychopharmacology Annual Conference, Waikoloa Village, Hawaii, December, 2001.
93. Rugle L, Bojrab S, Rosenthal R, Bernhard B. Olanzapine in the treatment of video poker pathological gamblers. Presented at the National Conference on Problem Gambling, Seattle, Wash, June, 2001.
94. Kim SW, Grant JE, Adson DE, Remmel RP. A preliminary report on possible naltrexone and nonsteroidal analgesics interaction. J Clin Psychopharmacol. In press.
95. Christensen MH, Patsdaughter CA, Babington LM. Health care providers' experiences with problem gamblers. J Gambl Stud. 2001;17:71–9. [PubMed] 96. Rowan MS, Galasso CS. Identifying office resource needs to help prevent, assess and treat patients with substance use and pathological gambling disorders. J Addict Dis. 2000;19:43–58. [PubMed]
97. Sullivan S. Development of the “EIGHT” Problem Gambling Screen. PhD Thesis. Auckland, New Zealand: Aucland Medical School; 1999.
98. Sullivan S, Arroll B, Coster G, Abbott M, Adams P. Problem gamblers: do GPs want to intervene. N Z Med J. 2000;113:204–7. [PubMed] 99. Johnson EE, Hamer R, Nora RM, Tan B. The Lie/Bet Questionnaire for screening pathological gamblers. Psychol Rep. 1997;80:83–8. [PubMed] 100. Johnson EE, Hamer RM, Nora RM. The Lie/Bet questionnaire for screening pathological gamblers: a follow-up study. Psychol Rep. 1998;83:1219–24. [PubMed] 101. Lesieur HR, Blume SB. The South Oaks Gambling Screen (SOGS): a new instrument for the identification of pathological gamblers. Am J Psychiatry. 1987;144:1184–8. [PubMed]
102. Sullivan S, Brown R, Adams P, Skinner B, Gerdaelan R. Development of a problem gambling screen for use in a prison inmate population. egambling. The Electronic Journal of Gambling Issues. In press.
103. Potenza MN. Pathological gambling: clinical aspects and neurobiology. In: Soares JC, Gershon S, editors. Handbook of Medical Psychiatry. New York: Marcel Dekker, Inc.; In press.