969 Maybe if UK hospitals had electronic records equal to ours in general practice, they could cut their rates of venous thromboembolism by 40%. This happened in an US trial of a computer alert for identifying high-risk surgical patients.
1061 Here is the study that proved celecoxib was not a safe alternative to rofecoxib. Both drugs were tried out for the prevention of colorectal adenoma, but both trials were stopped early because of an increased rate of cardiovascular morbidity and mortality – rofecoxib being the more dangerous (see page 1092).
1112 Serotonin reuptake inhibitors are relatively safe drugs on their own, but beware of combining them with other drugs such as synthetic opioids (e.g. tramadol), tricyclics, sumatriptan, valproate and St John's wort. The resulting serotonin syndrome is nasty and occasionally fatal.
1179 Expect more of your post-myocardial infarction patients to be taking clopidogrel as well as aspirin, following this trial showing improved outcomes after thrombolysis.
1206 The wee small hours are a low-risk time for myocardial infarction, unless you have obstructive sleep apnoea, in which case your risk increases threefold. This is reduced by continuous positive pressure ventilation (see Lancet page 1046).
1293 Gender protects women from cardiac events, but aspirin does not. It does, however, reduce their risk of stroke.