PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of bmjcredLink to Publisher's site
 
Br Med J (Clin Res Ed). 1984 December 1; 289(6457): 1495–1497.
PMCID: PMC1443742

Do antihypertensive drugs precipitate diabetes?

Abstract

A longitudinal population study of 1462 women aged 38-60 was carried out from 1968-9 to 1980-1 in Gothenburg, Sweden. The initial and follow up examinations included questions concerning history of diabetes and antihypertensive treatment. A considerably increased risk of developing diabetes was observed for subjects with hypertension taking diuretics (895 patient years), subjects taking beta blockers (682 patient years), and subjects taking a combination of diuretics and beta blockers (281 patient years) compared with subjects not taking antihypertensive drugs (13 855 control years). When diuretics and beta blockers were compared no difference was found in relative risk. Despite this increased risk, and because little is known about the relation between other forms of antihypertensive treatment and diabetes, diuretics and beta blockers should remain the treatments of choice in arterial hypertension.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (687K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bengtsson C, Lennartsson J, Lindquist O, Lindstedt G, Lundberg PA, Noppa H, Sigurdsson JA, Tibblin E. On metabolic effects of diuretics and beta-blockers. Results from a cross-sectional and longitudinal population study of women. Acta Med Scand. 1982;212(1-2):57–64. [PubMed]
  • Bengtsson C, Hallberg L, Hällström T, Hultborn A, Isaksson B, Lennartsson J, Lindquist O, Lindstedt S, Noppa H, Redvall L, et al. The population study of women in Göteborg 1974--1975--the second phase of a longitudinal study. General design, purpose and sampling results. Scand J Soc Med. 1978;6(2):49–54. [PubMed]
  • Miettinen O. Estimability and estimation in case-referent studies. Am J Epidemiol. 1976 Feb;103(2):226–235. [PubMed]
  • Barret-Connor E, Criqui MH, Klauber MR, Holdbrook M. Diabetes and hypertension in a community of older adults. Am J Epidemiol. 1981 Mar;113(3):276–284. [PubMed]
  • Drury PL. Diabetes and arterial hypertension. Diabetologia. 1983 Jan;24(1):1–9. [PubMed]
  • Furman BL. Impairment of glucose tolerance produced by diuretics and other drugs. Pharmacol Ther. 1981;12(3):613–649. [PubMed]
  • Sigurdsson JA, Bengtsson C, Lapidus L, Lindquist O, Rafnsson V. Morbidity and mortality in relation to blood pressure and antihypertensive treatment. A 12-year follow-up study of a population sample of Swedish women. Acta Med Scand. 1984;215(4):313–322. [PubMed]

Articles from British Medical Journal (Clinical Research Ed.) are provided here courtesy of BMJ Publishing Group