PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of procbThe Royal Society PublishingProceedings BAboutBrowse by SubjectAlertsFree Trial
 
Proc Biol Sci. 2004 December 7; 271(1556): 2523–2526.
PMCID: PMC1440519
NIHMSID: NIHMS8357

Fitness cost of extended lifespan in Caenorhabditis elegans.

Abstract

An insulin/IGF-I-like signalling pathway determines the rate of aging of the adult nematode, Caenorhabditis elegans. Mutations in genes encoding this pathway can result in a doubling of lifespan. While such mutations may appear to have little effect on development or fertility, evolutionary theory predicts that large increases in lifespan will not be optimal for fitness. We demonstrate by laboratory natural selection that partial loss of function of the insulin receptor-like protein DAF-2 results in dramatically reduced fitness even under laboratory conditions. Despite long-lived mutants appearing healthy, they exhibit a heavy fitness cost consistent with an evolutionary theory of aging.

Full Text

The Full Text of this article is available as a PDF (116K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Arantes-Oliveira Nuno, Berman Jennifer R, Kenyon Cynthia. Healthy animals with extreme longevity. Science. 2003 Oct 24;302(5645):611–611. [PubMed]
  • Blüher Matthias, Kahn Barbara B, Kahn C Ronald. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 2003 Jan 24;299(5606):572–574. [PubMed]
  • Dillin Andrew, Crawford Douglas K, Kenyon Cynthia. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science. 2002 Oct 25;298(5594):830–834. [PubMed]
  • Gems D, Sutton AJ, Sundermeyer ML, Albert PS, King KV, Edgley ML, Larsen PL, Riddle DL. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics. 1998 Sep;150(1):129–155. [PubMed]
  • Hodgkin J, Barnes TM. More is not better: brood size and population growth in a self-fertilizing nematode. Proc Biol Sci. 1991 Oct 22;246(1315):19–24. [PubMed]
  • Holzenberger Martin, Dupont Joëlle, Ducos Bertrand, Leneuve Patricia, Géloën Alain, Even Patrick C, Cervera Pascale, Le Bouc Yves. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003 Jan 9;421(6919):182–187. [PubMed]
  • Kirkwood TB, Holliday R. The evolution of ageing and longevity. Proc R Soc Lond B Biol Sci. 1979 Sep 21;205(1161):531–546. [PubMed]
  • Lakowski B, Hekimi S. Determination of life-span in Caenorhabditis elegans by four clock genes. Science. 1996 May 17;272(5264):1010–1013. [PubMed]
  • Marden James H, Rogina Blanka, Montooth Kristi L, Helfand Stephen L. Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3369–3373. [PubMed]
  • Sgrò CM, Partridge L. A delayed wave of death from reproduction in Drosophila. Science. 1999 Dec 24;286(5449):2521–2524. [PubMed]
  • Tatar Marc, Bartke Andrzej, Antebi Adam. The endocrine regulation of aging by insulin-like signals. Science. 2003 Feb 28;299(5611):1346–1351. [PubMed]
  • Walker DW, McColl G, Jenkins NL, Harris J, Lithgow GJ. Evolution of lifespan in C. elegans. Nature. 2000 May 18;405(6784):296–297. [PubMed]

Articles from Proceedings of the Royal Society B: Biological Sciences are provided here courtesy of The Royal Society