PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1980 January; 73(1): 29–33.
PMCID: PMC1440029

Value of fetoscopy in prenatal diagnosis1

Abstract

A technique of fetoscopy and fetoscopic blood sampling is described that makes maximum use of ultrasound scanning. A particle size analyser is also an integral part of the procedure. The results are based on 170 fetoscopies, 85 of which were performed for diagnostic reasons. The anterior placenta is rarely a cause of failure and in many instances makes fetal blood sampling easier. Pure fetal blood is obtainable from the umbilical cord insertion in 95% of cases sampled after 18 weeks' gestation. Fetal mortality may be as low as 3% and long-term adverse sequelae have not yet been discovered.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (749K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Benzie RJ, Malone RM, Miskin M, Rudd NL, Schofield PA. Prenatal diagnosis by fetoscopy with subsequent normal delivery: report of a case. Am J Obstet Gynecol. 1976 Sep 15;126(2):287–288. [PubMed]
  • Benzie RJ, Pirani BB. Fetoscopy and anterior placentas. N Engl J Med. 1977 Mar 10;296(10):573–573. [PubMed]
  • Fairweather DV, Modell B, Berdoukas V, Alter BP, Nathan DG, Loukopoulos D, Wood W, Clegg JB, Weatherall DJ. Antenatal diagnosis of thalassaemia major. Br Med J. 1978 Feb 11;1(6109):350–353. [PMC free article] [PubMed]
  • Fensom AH, Benson PF, Rodeck CH, Campbell S, Gould JD. Prenatal diagnosis of a galactosaemia heterozygote by fetal blood enzyme assay. Br Med J. 1979 Jan 6;1(6155):21–22. [PMC free article] [PubMed]
  • Golbus MS, Stephens JD, Mahoney MJ, Hobbins JC, Haseltine FP, Caskey CT, Banker BQ. Failure of fetal creatine phosphokinase as a diagnostic indicator of Duchenne muscular dystrophy. N Engl J Med. 1979 Apr 12;300(15):860–861. [PubMed]
  • Hobbins JC, Mahoney MJ. In utero diagnosis of hemoglobinopathies. Technic for obtaining fetal blood. N Engl J Med. 1974 May 9;290(19):1065–1067. [PubMed]
  • Hobbins JC, Mahoney MJ. Fetal blood drawing. Lancet. 1975 Jul 19;2(7925):107–109. [PubMed]
  • Hobbins JC, Mahoney MJ, Goldstein LA. New method of intrauterine evaluation by the combined use of fetoscopy and ultrasound. Am J Obstet Gynecol. 1974 Apr 15;118(8):1069–1072. [PubMed]
  • Kan YW, Trecartin RF, Golbus MS, Filly RA. Prenatal diagnosis of beta-thalassaemia and sickle-cell anaemia. Experience with 24 cases. Lancet. 1977 Feb 5;1(8006):269–271. [PubMed]
  • Kan YW, Valenti C, Carnazza V, Guidotti R, Rieder RF. Fetal blood-sampling in utero. Lancet. 1974 Jan 19;1(7847):79–80. [PubMed]
  • Laurence KM, Prosser R, Rocker I, Pearson JF, Richard C. Hirschsprung's disease associated with congenital heart malformation, broad big toes, and ulnar polydactyly in sibs: a case for fetoscopy. J Med Genet. 1975 Dec;12(4):334–338. [PMC free article] [PubMed]
  • Mibashan RS, Rodeck CH, Thumpston JK, Edwards RJ, Singer JD, White JM, Campbell S. Plasma assay of fetal factors VIIIC and IX for prenatal diagnosis of haemophilia. Lancet. 1979 Jun 23;1(8130):1309–1311. [PubMed]
  • Newburger PE, Cohen HJ, Rothchild SB, Hobbins JC, Malawista SE, Mahoney MJ. Prenatal diagnosis of chronic granulomatous disease. N Engl J Med. 1979 Jan 25;300(4):178–181. [PubMed]
  • Rauskolb R, Fuhrmann W. Die Fetoskopie. Z Geburtshilfe Perinatol. 1978 Aug;182(4):243–262. [PubMed]
  • Rodeck CH, Campbell S. Early prenatal diagnosis of neural-tube defects by ultrasound-guided fetoscopy. Lancet. 1978 May 27;1(8074):1128–1129. [PubMed]
  • Rodeck CH, Campbell S. Sampling pure fetal blood by fetoscopy in second trimester of pregnancy. Br Med J. 1978 Sep 9;2(6139):728–730. [PMC free article] [PubMed]
  • Rodeck CH, Campbell S. Umbilical-cord insertion as source of pure fetal blood for prenatal diagnosis. Lancet. 1979 Jun 9;1(8128):1244–1245. [PubMed]
  • Valenti C. Endoamnioscopy and fetal biopsy: a new technique. Am J Obstet Gynecol. 1972 Oct 15;114(4):561–564. [PubMed]
  • Valenti C. Antenatal detection of hemoglobinopathies. A preliminary report. Am J Obstet Gynecol. 1973 Mar 15;115(6):851–853. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press