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J R Soc Med. 1984 September; 77(9): 758–760.
PMCID: PMC1440002

Tympanic epithelium: an ultrastructural, experimental and clinical study.


Ultrastructural studies of the guinea pig tympanic membrane failed to reveal specific morphological features that could be associated with migration. A staining method was used to study epithelial migration on 68 normal guinea pig tympanic membranes. A very predictable migratory pattern emerged which was neither influenced by perforation or ventilating tube insertion. Clinical studies in children on 61 normal tympanic membranes revealed a rapid migration which was unchanged by middle ear effusion. A centrifugal pattern of migration was observed in relation to the 23 chronic perforations studied. The kinetics of epithelium in relation to 41 ventilating tubes and in 23 retraction pockets is described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bluestone CD. Otitis media in children: to treat or not to treat? N Engl J Med. 1982 Jun 10;306(23):1399–1404. [PubMed]
  • Clawson JP, Litton WB. The healing process of tympanic membrane perforations. Trans Am Acad Ophthalmol Otolaryngol. 1971 Nov-Dec;75(6):1302–1312. [PubMed]
  • Croft CB, Tarin D. Ultrastructural studies of wound healing in mouse skin. I. Epithelial behaviour. J Anat. 1970 Jan;106(Pt 1):63–77. [PubMed]
  • Gundersen T, Tonning FM. Ventilating tubes in the middle ear. Arch Otolaryngol. 1976 Apr;102(4):198–199. [PubMed]
  • McMinn RM, Taylor M. The cytology of repair in experimental perforations of the tympanic membrane. Br J Surg. 1966 Mar;53(3):222–232. [PubMed]
  • O'Donoghue GM. Epithelial migration on the guinea-pig tympanic membrane: the influence of perforation and ventilating tube insertion. Clin Otolaryngol Allied Sci. 1983 Oct;8(5):297–303. [PubMed]
  • Sadé J. Pathogenesis of attic cholesteatomas. J R Soc Med. 1978 Oct;71(10):716–732. [PMC free article] [PubMed]

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