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J R Soc Med. 1984 May; 77(5): 372–374.
PMCID: PMC1439899

Painful extremities and neurological disorder in essential thrombocythaemia.


Six of 20 patients with essential thrombocythaemia had neurological features and 8 had peripheral vascular symptoms. Four had cerebrovascular ischaemia or stroke and 3 had gangrene. Pain in the extremities may be a striking symptom in this disorder.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Hoagland HC, Silverstein MN. Primary thrombocythemia in the young patient. Mayo Clin Proc. 1978 Sep;53(9):578–580. [PubMed]
  • Korenman G. Neurologic syndromes associated with primary thrombocythemia. J Mt Sinai Hosp N Y. 1969 Jul-Aug;36(4):317–323. [PubMed]
  • Levine J, Swanson PD. Idiopathic thrombocytosis. A treatable cause of transient ischemic attacks. Neurology. 1968 Jul;18(7):711–713. [PubMed]
  • Preston FE. Essential thrombocythaemia. Lancet. 1982 May 1;1(8279):1021–1021. [PubMed]
  • Preston FE, Martin JF, Stewart RM, Davies-Jones GA. Thrombocytosis, circulating platelet aggregates, and neurological dysfunction. Br Med J. 1979 Dec 15;2(6204):1561–1563. [PMC free article] [PubMed]
  • SPACH MS, HOWELL DA, HARRIS JS. Myocardial infarction and multiple thromboses in a child with primary thrombocytosis. Pediatrics. 1963 Feb;31:268–276. [PubMed]

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