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J R Soc Med. 1984 June; 77(6): 472–477.
PMCID: PMC1439786

Assessment of sutures for use in colonic surgery: an experimental study.


Following injury, normal colon takes approximately 30 days to regain full breaking strength. This healing period can be lengthened by local infection. Colonic anastomoses are likely to be contaminated by intraluminal organisms, and suture material in such a situation is known to potentiate the development of sepsis. Experiments were designed to evaluate six suture materials used in colonic surgery to determine which retained adequate tensile strength and which excited least inflammatory response. The results indicate that absorbable sutures, with the exception of polydioxanone, lose strength too rapidly for use alone. Braided materials, notably silk, produce a prolonged tissue response and harbour bacteria. Monofilament materials are unreactive and appear least likely to delay healing. Polydioxanone, which is monofilament and absorbable, is recommended for use in the colon.

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Selected References

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  • Cronin K, Jackson DS, Dunphy JE. Specific activity of hydroxyproline-tritium in the healing colon. Surg Gynecol Obstet. 1968 May;126(5):1061–1065. [PubMed]
  • Edlich RF, Tsung MS, Rogers W, Rogers P, Wangensteen OH. Studies in management of the contaminated wound. I. Technique of closure of such wounds together with a note on a reproducible experimental model. J Surg Res. 1968 Dec;8(12):585–592. [PubMed]
  • ELEK SD, CONEN PE. The virulence of Staphylococcus pyogenes for man; a study of the problems of wound infection. Br J Exp Pathol. 1957 Dec;38(6):573–586. [PubMed]
  • Fielding LP, Stewart-Brown S, Blesovsky L, Kearney G. Anastomotic integrity after operations for large-bowel cancer: a multicentre study. Br Med J. 1980 Aug 9;281(6237):411–414. [PMC free article] [PubMed]
  • Fontaine CJ, Dudley HA. Assessment of suture materials for intestinal use by an extramucosal implant technique and a quantitative histological evaluation. Br J Surg. 1978 Apr;65(4):288–290. [PubMed]
  • Goligher JC, Graham NG, De Dombal FT. Anastomotic dehiscence after anterior resection of rectum and sigmoid. Br J Surg. 1970 Feb;57(2):109–118. [PubMed]
  • Hawley PR. Causes and prevention of colonic anastomotic breakdown. Dis Colon Rectum. 1973 Jul-Aug;16(4):272–277. [PubMed]
  • JAMES RC, MACLEOD CJ. Induction of staphylococcal infections in mice with small inocula introduced on sutures. Br J Exp Pathol. 1961 Jun;42:266–277. [PubMed]
  • LeVeen HH, Wapnick S, Falk G, Olivas O, Bhat D, Gaurdre M, Patel M. Effects of prophylactic antibiotics on colonic healing. Am J Surg. 1976 Jan;131(1):47–53. [PubMed]
  • Morgenstern L, Yamakawa T, Ben-Shoshan M, Lippman H. Anastomotic leakage after low colonic anastomosis. Clinical and experimental aspects. Am J Surg. 1972 Jan;123(1):104–109. [PubMed]
  • Schrock TR, Deveney CW, Dunphy JE. Factor contributing to leakage of colonic anastomoses. Ann Surg. 1973 May;177(5):513–518. [PubMed]
  • Varma S, Ferguson HL, Breen H, Lumb WV. Comparison of seven suture materials in infected wounds--an experimental study. J Surg Res. 1974 Sep;17(3):165–170. [PubMed]
  • Wilkins JL, Hardcastle JD, Mann CV, Kaufman L. Effects of neostigmine and atropine on motor activity of ileum, colon, and rectum of anaesthetized subjects. Br Med J. 1970 Mar 28;1(5699):793–794. [PMC free article] [PubMed]
  • Greatorex G, Whitaker BL, Dixon RA. Anastomotic failure in relation to blood transfusion and blood loss. Proc R Soc Med. 1970 Aug;63(8):751–751. [PMC free article] [PubMed]
  • Yamakawa T, Patin CS, Sobel S, Morgenstern L. Healing of colonic anastomoses following resection for experimental "diverticulitis". Arch Surg. 1971 Jul;103(1):17–20. [PubMed]

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