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J R Soc Med. 1984 February; 77(2): 120–124.
PMCID: PMC1439719

Histamine and its release from nasal polyps: preliminary communication.


Two hundred consecutive patients admitted for polypectomy had no evidence of an increased incidence of allergic disorders. Mast cell degranulation was found on transmission electron microscopy and this resulted in considerable quantities of histamine in polyp extracellular fluid (124-7300 ng/ml). RAST levels of allergen-specific IgE to house-dust mite and mixed-grass pollens were raised in 4 out of 28 cases in polyp fluid, and in only one matched serum. In vitro challenge of polyp tissue with allergen extract and anti-IgE suggested an IgE-mediated response in only 4 of 36 patients.

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Selected References

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  • Busuttil A, More IA, McSeveney D. Ultrastructure of the stroma of nasal polyps: cilia in stromal fibroblasts. Arch Otolaryngol. 1976 Oct;102(10):589–595. [PubMed]
  • Caplin I, Haynes JT, Spahn J. Are nasal polyps an allergic phenomenon? Ann Allergy. 1971 Dec;29(12):631–634. [PubMed]
  • Caulfield JP, Lewis RA, Hein A, Austen KF. Secretion in dissociated human pulmonary mast cells. Evidence for solubilization of granule contents before discharge. J Cell Biol. 1980 May;85(2):299–312. [PMC free article] [PubMed]
  • Cauna N, Manzetti GW, Hinderer KH, Swanson EW. Fine structure of nasal polyps. Ann Otol Rhinol Laryngol. 1972 Feb;81(1):41–58. [PubMed]
  • Ceska M, Eriksson R, Varga JM. Radioimmunosorbent assay of allergens. J Allergy Clin Immunol. 1972 Jan;49(1):1–9. [PubMed]
  • Donovan R, Johansson SG, Bennich H, Soothill JF. Immunoglobulins in nasal polyp fluid. Int Arch Allergy Appl Immunol. 1970;37(2):154–166. [PubMed]
  • Drake-Lee AB, McLaughlan P. Clinical symptoms, free histamine and IgE in patients with nasal polyposis. Int Arch Allergy Appl Immunol. 1982;69(3):268–271. [PubMed]
  • Lee AB, Pitcher-Wilmott RW. The clinical and laboratory correlates of nasal polyps in cystic fibrosis. Int J Pediatr Otorhinolaryngol. 1982 Aug;4(3):209–214. [PubMed]
  • Evans DP, Lewis JA, Thomson DS. An automated fluorimetric assay for the rapid determination of histamine in biological fluids. Life Sci II. 1973 Apr 8;12(7):327–336. [PubMed]
  • GIBBONS IR, GRIMSTONE AV. On flagellar structure in certain flagellates. J Biophys Biochem Cytol. 1960 Jul;7:697–716. [PMC free article] [PubMed]
  • John AC, Merrett TG. The radioallergosorbent test (RAST) in nasal polyposis. J Laryngol Otol. 1979 Sep;93(9):889–898. [PubMed]
  • Kaliner M, Wasserman SI, Austen KF. Immunologic release of chemical mediators from human nasal polyps. N Engl J Med. 1973 Aug 9;289(6):277–281. [PubMed]
  • McLaughlan P, Coombs RR. Latent anaphylactic sensitivity of infants to cow's milk proteins. Histamine release from blood basophils. Clin Allergy. 1983 Jan;13(1):1–9. [PubMed]
  • Moloney JR, Collins J. Nasal polyps and bronchial asthma. Br J Dis Chest. 1977 Jan;71(1):1–6. [PubMed]
  • Norman PS, Lichtenstein LM, Ishizaka K. Diagnostic tests in ragweed hay fever. A comparison of direct skin tests, IgE antibody measurements, and basophil histamine release. J Allergy Clin Immunol. 1973 Oct;52(4):210–224. [PubMed]
  • Radermecker MF. Allergen-mediated histamine release from whole blood. Clinical evaluation. Int Arch Allergy Appl Immunol. 1980;63(4):415–423. [PubMed]
  • REYNOLDS ES. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963 Apr;17:208–212. [PMC free article] [PubMed]
  • SAMTER M. Nasal polyps: their relationship to allergy, particularly to bronchial asthma. Med Clin North Am. 1958 Jan;42(1):175–179. [PubMed]
  • Wide L, Bennich H, Johansson SG. Diagnosis of allergy by an in-vitro test for allergen antibodies. Lancet. 1967 Nov 25;2(7526):1105–1107. [PubMed]
  • Wilson JA. Nasal polypi. Clin Otolaryngol Allied Sci. 1976;1(1):4–6. [PubMed]

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