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J R Soc Med. 1983 September; 76(9): 743–746.
PMCID: PMC1439413

Some factors affecting nerve regeneration in relation to radiotherapy.

Abstract

The effect of delay and irradiation, both separately and combined, on regeneration of rat sciatic nerve was evaluated in adult Wistar rats. Those animals which had received irradiation at some stage fared significantly worse than those which had immediate division and reanastomosis of the sciatic nerve without irradiation. The possible relevance of these findings to nerve regeneration in patients treated by surgery and radiotherapy for parotid cancer is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • CONLEY JJ. Facial nerve grafting. Arch Otolaryngol. 1961 Mar;73:322–327. [PubMed]
  • Conley J, Hamaker RC. Prognosis of malignant tumors of the parotid gland with facial paralysis. Arch Otolaryngol. 1975 Jan;101(1):39–41. [PubMed]
  • Eneroth CM, Hamberger CA. Principles of treatment of different types of parotid tumors. Laryngoscope. 1974 Oct;84(10):1732–1740. [PubMed]
  • Fletcher GH, Jessee RH. The place of irradiation in the management of the primary lesion in head and neck cancers. Cancer. 1977 Feb;39(2 Suppl):862–867. [PubMed]
  • LATHROP FD. MANAGEMENT OF THE FACIAL NERVE DURING OPERATIONS ON THE PAROTID GLAND. Ann Otol Rhinol Laryngol. 1963 Sep;72:780–801. [PubMed]
  • McCabe BF. Facial nerve grafting. Plast Reconstr Surg. 1970 Jan;45(1):70–75. [PubMed]
  • Miehlke A, Stennert E, Schuster R, Schätzle W, Haubrich J. Uber die Regeneration peripherer Nerven nach Einwirkung ionisierender Strahlen. ORL J Otorhinolaryngol Relat Spec. 1972;34(2):88–100. [PubMed]
  • Stearns MP. The effect of irradiation on nerve grafting. Clin Otolaryngol Allied Sci. 1982 Jun;7(3):161–164. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press