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J R Soc Med. 1981 November; 74(11): 810–813.
PMCID: PMC1439380

Potential role of cyclosporin A in corneal grafting.


The immunosuppressive drug cyclosporin A has been shown to be effective in preventing corneal allograft reactions in rabbits when administered by intramuscular injection. However, when used systemically in man, the drug may have potentially serious side effects and a series of experiments has therefore been performed in order to investigate the use of topically applied cyclosporin A in rabbit corneal transplants. Using a single set model of the corneal allograft reaction, two groups of rabbits treated with topically applied cyclosporin A for periods of four and thirteen weeks respectively showed significantly increased graft survival compared with untreated controls (P less than 0.001).

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Selected References

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  • Calne RY, White DJ, Evans DB, Thiru S, Henderson RG, Hamilton DV, Rolles K, McMaster P, Duffy TJ, MacDougall BR, et al. Cyclosporin A in cadaveric organ transplantation. Br Med J (Clin Res Ed) 1981 Mar 21;282(6268):934–936. [PMC free article] [PubMed]
  • Calne RY, White DJ, Rolles K, Smith DP, Herbertson BM. Prolonged survival of pig orthotopic heart grafts treated with cyclosporin A. Lancet. 1978 Jun 3;1(8075):1183–1185. [PubMed]
  • Donshik PC, Cavanagh HD, Boruchoff SA, Dohlman CH. Effect of bilateral and unilateral grafts on the incidence of rejections in keratoconus. Am J Ophthalmol. 1979 Jun;87(6):823–826. [PubMed]
  • Green CJ, Allison AC, Precious S. Induction of specific tolerance in rabbits by kidney allografting and short periods of cyclosporin-A treatment. Lancet. 1979 Jul 21;2(8134):123–125. [PubMed]
  • Hamilton DV, Calne RY, Evans DB, Henderson RG, Thiru S, White DJ. The effect of long-term cyclosporin A on renal function. Lancet. 1981 May 30;1(8231):1218–1219. [PubMed]
  • Hunter PA, Wilhelmus KR, Rice NS, Jones BR. Cyclosporin A applied topically to the recipient eye inhibits corneal graft rejection. Clin Exp Immunol. 1981 Jul;45(1):173–177. [PubMed]
  • Shepherd WF, Coster DJ, Fook TC, Rice NS, Jones BR. Effect of cyclosporin A on the survival of corneal grafts in rabbits. Br J Ophthalmol. 1980 Mar;64(3):148–153. [PMC free article] [PubMed]
  • Tutschka PJ, Beschorner WE, Allison AC, Burns WH, Santos GW. Use of cyclosporin A in allogeneic bone marrow transplantation in the rat. Nature. 1979 Jul 12;280(5718):148–151. [PubMed]

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