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J R Soc Med. 1981 November; 74(11): 794–799.
PMCID: PMC1439334

Observations on chronic polyarthritis in monkeys1


Erosion and inflammatory changes in the carpus, fingers and toes of a rhesus monkey, Macaca mulatta, are described; this was one of 152 animals in each of which four fixed limbs were available for examination. The histological changes resembled closely those found in adult human rheumatoid arthritis. The limited literature is reviewed (including cases with amyloid disease).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bramblett CA. Pathology in the Darajani baboon. Am J Phys Anthropol. 1967 May;26(3):331–340. [PubMed]
  • Brown TM, Clark HW, Bailey JS, Gray CW. A mechanistic approach to treatment of rheumatoid type arthritis naturally occurring in a gorilla. Trans Am Clin Climatol Assoc. 1971;82:227–247. [PubMed]
  • Clinicopathological conference. A case of early ankylosing spondylitis with fatal secondary amyloidosis. Br Med J. 1968 May 18;2(5602):412–416. [PMC free article] [PubMed]
  • Bywaters EG, Dixon AS. Paravertebral ossification in psoriatic arthritis. Ann Rheum Dis. 1965 Jul;24(4):313–331. [PMC free article] [PubMed]
  • Casey HW, Kirk JH, Splitter GA. Generalized amyloidosis in a rhesus monkey. Lab Anim Sci. 1972 Aug;22(4):587–593. [PubMed]
  • GILLMAN J, GILBERT C. Primary amyloidosis in the baboon (Papio ursinus); its relationship to macromolecular syndromes and diseases of the connective tissues. Acta Med Scand Suppl. 1955;306:155–189. [PubMed]
  • Holmberg CA, Terrell TG, Osburn BI. Lymphocyte subpopulations in spontaneous disease of rhesus macaques. Am J Vet Res. 1977 Nov;38(11):1855–1860. [PubMed]
  • Obeck DK, Toft JD, 2nd, Dupey H. Severe polyarthritis in a rhesus monkey: suggested Mycoplasma etiology. Lab Anim Sci. 1976 Aug;26(4):613–618. [PubMed]
  • Sokoloff L, Snell KC, Stewart HL. Spinal ankylosis in old Rhesus monkeys. Clin Orthop Relat Res. 1968 Nov-Dec;61:285–293. [PubMed]

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