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J R Soc Med. 1983 August; 76(8): 635–642.
PMCID: PMC1439277

Systemic sclerosis--a microvascular disorder?

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Selected References

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  • Boucek RJ, Noble NL. Histamine, norepinephrine, and bradykinin stimulation of fibroblast growth and modification of serotonin response. Proc Soc Exp Biol Med. 1973 Dec;144(3):929–933. [PubMed]
  • Boucek RJ, Speropoulos AJ, Noble NL. Serotonin and ribonucleic acid and collagen metabolism of fibroblasts in vitro. Proc Soc Exp Biol Med. 1972 Jun;140(2):599–603. [PubMed]
  • Browse NL, Jarrett PE, Morland M, Burnand K. Treatment of liposclerosis of the leg by fibrinolytic enhancement: a preliminary report. Br Med J. 1977 Aug 13;2(6084):434–435. [PMC free article] [PubMed]
  • Burnand KG, Whimster I, Naidoo A, Browse NL. Pericapillary fibrin in the ulcer-bearing skin of the leg: the cause of lipodermatosclerosis and venous ulceration. Br Med J (Clin Res Ed) 1982 Oct 16;285(6348):1071–1072. [PMC free article] [PubMed]
  • Campbell PM, LeRoy EC. Pathogenesis of systemic sclerosis: a vascular hypothesis. Semin Arthritis Rheum. 1975 May;4(4):351–368. [PubMed]
  • Cannon PJ, Hassar M, Case DB, Casarella WJ, Sommers SC, LeRoy EC. The relationship of hypertension and renal failure in scleroderma (progressive systemic sclerosis) to structural and functional abnormalities of the renal cortical circulation. Medicine (Baltimore) 1974 Jan;53(1):1–46. [PubMed]
  • Castor CW, Ritchie JC, Williams CH, Jr, Scott ME, Whitney SL, Myers SL, Sloan TB, Anderson BE. Connective tissue activation. XIV. Composition and actions of a human platelet autacoid mediator. Arthritis Rheum. 1979 Mar;22(3):260–272. [PubMed]
  • Coffman JD, Cohen AS. Total and capillary fingertip blood flow in Raynaud's phenomenon. N Engl J Med. 1971 Jul 29;285(5):259–263. [PubMed]
  • Cunliffe WJ, Menon IS. Blood fibrinolytic activity in diseases of small blood vessels and the effect of low molecular weight dextran. Br J Dermatol. 1969 Mar;81(3):220–225. [PubMed]
  • Dabich L, Bookstein JJ, Zweifler A, Zarafonetis CJ. Digital arteries in patients with scleroderma. Arteriographic and plethysmographic study. Arch Intern Med. 1972 Nov;130(5):708–714. [PubMed]
  • D'Angelo WA, Fries JF, Masi AT, Shulman LE. Pathologic observations in systemic sclerosis (scleroderma). A study of fifty-eight autopsy cases and fifty-eight matched controls. Am J Med. 1969 Mar;46(3):428–440. [PubMed]
  • Dodds AJ, O'Reilly MJ, Yates CJ, Cotton LT, Flute PT, Dormandy JA. Haemorrheological response to plasma exchange in Raynaud's syndrome. Br Med J. 1979 Nov 10;2(6199):1186–1187. [PMC free article] [PubMed]
  • Dowd PM, Kovacs IB, Bland CJ, Kirby JD. Effect of prostaglandins I2 and E1 on red cell deformability in patients with Raynaud's phenomenon and systemic sclerosis. Br Med J (Clin Res Ed) 1981 Aug 1;283(6287):350–350. [PMC free article] [PubMed]
  • Emmanuel G, Saroja D, Gopinathan K, Gharpure A, Stuckey J. Environmental factors and the diffusing capacity of the lung in progressive systemic sclerosis. Chest. 1976 Feb;69(2 Suppl):304–307. [PubMed]
  • Fagrell B. The skin microcirculation and the pathogenesis of ischaemic necrosis and gangrene. Scand J Clin Lab Invest. 1977 Oct;37(6):473–476. [PubMed]
  • FENNELL RH, Jr, REDDY CR, VAZQUEZ JJ. Progressive systemic sclerosis and malignant hypertension. Immunohistochemical study of renal lesions. Arch Pathol. 1961 Aug;72:209–215. [PubMed]
  • Fries JF, Lindgren JA, Bull JM. Scleroderma-like lesions and the carcinoid syndrome. Arch Intern Med. 1973 Apr;131(4):550–553. [PubMed]
  • Fleischmajer R, Perlish JS, Shaw KV, Pirozzi DJ. Skin capillary changes in early systemic scleroderma. Electron microscopy and "in vitro" autoradiography with tritiated thymidine. Arch Dermatol. 1976 Nov;112(11):1553–1557. [PubMed]
  • Furey NL, Schmid FR, Kwaan HC, Friederici HH. Arterial thrombosis in scleroderma. Br J Dermatol. 1975 Dec;93(6):683–693. [PubMed]
  • Furst DE, Davis JA, Clements PJ, Chopra SK, Theofilopoulos AN, Chia D. Abnormalities of pulmonary vascular dynamics and inflammation in early progressive systemic sclerosis. Arthritis Rheum. 1981 Nov;24(11):1403–1408. [PubMed]
  • Gay RE, Buckingham RB, Prince RK, Gay S, Rodnan GP, Miller EJ. Collagen types synthesized in dermal fibroblast cultures from patients with early progressive systemic sclerosis. Arthritis Rheum. 1980 Feb;23(2):190–196. [PubMed]
  • Goyle KB, Dormandy JA. Abnormal blood viscosity in Raynaud's phenomenon. Lancet. 1976 Jun 19;1(7973):1317–1318. [PubMed]
  • Nilsen KH, Jayson MI. Cutaneous microcirculation in systemic sclerosis and response to intra-arterial reserpine. Br Med J. 1980 Jun 14;280(6229):1408–1411. [PMC free article] [PubMed]
  • HALPERN A, KUHN PH, SHAFTEL HE, SAMUELS SS, SHAFTEL N, SELMAN D, BRICH HG. Raynaud's disease, Raynaud's phenomenon, and serotonin. Angiology. 1960 Jun;11:151–167. [PubMed]
  • HINES RA. Peripheral neuritis following isoniazid therapy; appearance of Dupuytren's contracture and Raynaud's phenomenon. J Am Med Assoc. 1955 Nov 19;159(12):1197–1198. [PubMed]
  • Hope W, Martin TJ, Chesterman CN, Morgan FJ. Human beta-thromboglobulin inhibits PGI2 production and binds to a specific site in bovine aortic endothelial cells. Nature. 1979 Nov 8;282(5735):210–212. [PubMed]
  • Husson JM, Druet P, Contet A, Fiessinger JN, Camilleri JP. Systemic sclerosis and cryoglobulinemia. Clin Immunol Immunopathol. 1976 Jul;6(1):77–82. [PubMed]
  • Jarrett PE, Morland M, Browse NL. Treatment of Raynaud's phenomenon by fibrinolytic enhancement. Br Med J. 1978 Aug 19;2(6136):523–525. [PMC free article] [PubMed]
  • Johnson RL, Ziff M. Lymphokine stimulation of collagen accumulation. J Clin Invest. 1976 Jul;58(1):240–252. [PMC free article] [PubMed]
  • Kahaleh MB, Osborn I, LeRoy EC. Increased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in scleroderma and in Raynaud's phenomenon. Ann Intern Med. 1981 Apr;94(4 Pt 1):482–484. [PubMed]
  • Kahaleh MB, Osborn I, Leroy EC. Elevated levels of circulating platelet aggregates and beta-thromboglobulin in scleroderma. Ann Intern Med. 1982 May;96(5):610–613. [PubMed]
  • Kahaleh MB, Sherer GK, LeRoy EC. Endothelial injury in scleroderma. J Exp Med. 1979 Jun 1;149(6):1326–1335. [PMC free article] [PubMed]
  • Lapenas D, Rodnan GP, Cavallo T. Immunopathology of the renal vascular lesion of progressive systemic sclerosis (scleroderma). Am J Pathol. 1978 May;91(2):243–258. [PubMed]
  • LeRoy EC, Downey JA, Cannon PJ. Skin capillary blood flow in scleroderma. J Clin Invest. 1971 Apr;50(4):930–939. [PMC free article] [PubMed]
  • MACDONALD RA, ROBBINS SL, MALLORY GK. Dermal fibrosis following subcutaneous injections of serotonin creatinine sulphate. Proc Soc Exp Biol Med. 1958 Feb;97(2):334–337. [PubMed]
  • McGrath MA, Peek R, Penny R. Blood hyperviscosity with reduced skin blood flow in scleroderma. Ann Rheum Dis. 1977 Dec;36(6):569–574. [PMC free article] [PubMed]
  • Mackel AM, DeLustro F, Harper FE, LeRoy EC. Antibodies to collagen in scleroderma. Arthritis Rheum. 1982 May;25(5):522–531. [PubMed]
  • Maricq HR. Wide-field capillary microscopy. Arthritis Rheum. 1981 Sep;24(9):1159–1165. [PubMed]
  • Maricq HR, LeRoy EC, D'Angelo WA, Medsger TA, Jr, Rodnan GP, Sharp GC, Wolfe JF. Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders. Arthritis Rheum. 1980 Feb;23(2):183–189. [PubMed]
  • Maricq HR, Spencer-Green G, LeRoy EC. Skin capillary abnormalities as indicators of organ involvement in scleroderma (systemic sclerosis), Raynaud's syndrome and dermatomyositis. Am J Med. 1976 Dec;61(6):862–870. [PubMed]
  • Maricq HR, Weinberger AB, LeRoy EC. Early detection of scleroderma-spectrum disorders by in vivo capillary microscopy: a prospective study of patients with Raynaud's phenomenon. J Rheumatol. 1982 Mar-Apr;9(2):289–291. [PubMed]
  • Martin MF, Tooke JE. Effects of prostaglandin E1 on microvascular haemodynamics in progressive systemic sclerosis. Br Med J (Clin Res Ed) 1982 Dec 11;285(6356):1688–1690. [PMC free article] [PubMed]
  • Norton WL. Comparison of the microangiopathy of systemic lupus erythematosus, dermatomyositis, scleroderma, and diabetes mellitus. Lab Invest. 1970 Apr;22(4):301–308. [PubMed]
  • Norton WL, Nardo JM. Vascular disease in progressive systemic sclerosis (scleroderma). Ann Intern Med. 1970 Aug;73(2):317–324. [PubMed]
  • O'Reilly MJ, Talpos G, Roberts VC, White JM, Cotton LT. Controlled trial of plasma exchange in treatment of Raynaud's syndrome. Br Med J. 1979 Apr 28;1(6171):1113–1115. [PMC free article] [PubMed]
  • PEACOCK JH. Peripheral venous blood concentrations of epinephrine and norepinephrine in primary Raynaud's disease. Circ Res. 1959 Nov;7:821–827. [PubMed]
  • RODDIE IC, SHEPHERD JT, WHELAN RF. The action of 5-hydroxytryptamine on the blood vessels of the human hand and forearm. Br J Pharmacol Chemother. 1955 Dec;10(4):445–450. [PubMed]
  • Rosenbloom AL, Silverstein JH, Lezotte DC, Richardson K, McCallum M. Limited joint mobility in childhood diabetes mellitus indicates increased risk for microvascular disease. N Engl J Med. 1981 Jul 23;305(4):191–194. [PubMed]
  • ROSSI P, ZAMBONI L. Pulmonary arteriosclerosis due to serotonin. Nature. 1958 Apr 26;181(4617):1216–1217. [PubMed]
  • Sakariassen KS, Bolhuis PA, Sixma JJ. Platelet adherence to subendothelium of human arteries in pulsatile and steady flow. Thromb Res. 19(4-5):547–559. [PubMed]
  • Salyer WR, Salyer DC, Heptinstall RH. Scleroderma and microangiopathic hemolytic anemia. Ann Intern Med. 1973 Jun;78(6):895–897. [PubMed]
  • Sapira JD, Rodnan GP, Scheib ET, Klaniecki T, Rizk M. Studies of endogenous catecholamines in patients with Raynaud's phenomenon secondary to progressive systemic sclerosis (scleroderma). Am J Med. 1972 Mar;52(3):330–337. [PubMed]
  • Seibold JR. Digital sclerosis in children with insulin-dependent diabetes mellitus. Arthritis Rheum. 1982 Nov;25(11):1357–1361. [PubMed]
  • Seibold JR, Medsger TA, Jr, Winkelstein A, Kelly RH, Rodnan GP. Immune complexes in progressive systemic sclerosis (scleroderma). Arthritis Rheum. 1982 Oct;25(10):1167–1173. [PubMed]
  • Sharp GC, Irvin WS, Tan EM, Gould RG, Holman HR. Mixed connective tissue disease--an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med. 1972 Feb;52(2):148–159. [PubMed]
  • Siminovitch K, Klein M, Pruzanski W, Wilkinson S, Lee P, Yoon SJ, Keystone E. Circulating immune complexes in patients with progressive systemic sclerosis. Arthritis Rheum. 1982 Oct;25(10):1174–1179. [PubMed]
  • Stachow A, Jablonska S, Skiendzielewska A. 5-Hydroxytryptamine and tryptamine pathways in scleroderma. Br J Dermatol. 1977 Aug;97(2):147–154. [PubMed]
  • Stachów A, Jabłońska S, Skiendzielewska A. Biogenic amines derived from tryptophan in systemic and cutaneous scleroderma. Acta Derm Venereol. 1979;59(1):1–5. [PubMed]
  • Sternberg EM, Van Woert MH, Young SN, Magnussen I, Baker H, Gauthier S, Osterland CK. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. N Engl J Med. 1980 Oct 2;303(14):782–787. [PubMed]
  • Tan EM, Pearson CM. Rheumatic disease sera reactive with capillaries in the mouse kidney. Arthritis Rheum. 1972 Jan-Feb;15(1):23–28. [PubMed]
  • Wasner C, Cooke CR, Fries JF. Successful medical treatment of scleroderma renal crisis. N Engl J Med. 1978 Oct 19;299(16):873–875. [PubMed]
  • Whitman HH, 3rd, Case DB, Laragh JH, Christian CL, Botstein G, Maricq H, Leroy EC. Variable response to oral angiotensin-converting-enzyme blockade in hypertensive scleroderma patients. Arthritis Rheum. 1982 Mar;25(3):241–248. [PubMed]
  • Winkelmann RK, Goldyne ME, Linscheid RL. Hypersensitivity of scleroderma cutaneous vascular smooth muscle to 5-hydroxytryptamine. Br J Dermatol. 1976 Jul;95(1):51–56. [PubMed]
  • Winkelmann RK, Goldyne ME, Linscheid RL. Influence of cold on catecholamine response of vascular smooth muscle strips from resistance vessels of scleroderma skin. Angiology. 1977 May;28(5):330–339. [PubMed]

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