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J R Soc Med. 1983 May; 76(5): 369–371.
PMCID: PMC1439176

Intravenous glycopyrrolate and atropine at induction of anaesthesia: a comparison.


In unpremedicated patients presenting for general anaesthesia for electroconvulsive therapy (ECT), the use of atropine combined with methohexitone as an intravenous induction agent was found to produce a significantly greater increase in heart rate than glycopyrrolate in similar combination. There was no difference in the antisialogogue effect of the two drugs at the doses used, and both drugs provided similar protection against the effects of suxamethonium and ECT on heart rate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bernhoff A, Eklund B, Kaijser L. Cardiovascular effects of short-term anaesthesia with methohexitone and propanidid in normal subjects. Br J Anaesth. 1972 Jan;44(1):2–7. [PubMed]
  • LUPPRIAN KG, CHURCHILL-DAVIDSON HC. Effect of suxamethonium on cardiac rhythm. Br Med J. 1960 Dec 17;2(5215):1774–1777. [PMC free article] [PubMed]
  • McCubbin TD, Brown JH, Dewar KM, Jones CJ, Spence AA. Glycopyrrolate as a premedicant: comparison with atropine. Br J Anaesth. 1979 Sep;51(9):885–889. [PubMed]
  • Mirakhur RK, Clarke RS, Dundee JW, McDonald JR. Anticholinergic drugs in anaesthesia. A survey of their present position. Anaesthesia. 1978 Feb;33(2):133–138. [PubMed]
  • Mirakhur RK, Clarke RS, Elliott J, Dundee JW. Atropine and glycopyrronium premedication. A comparison of the effects on cardiac rate and rhythm during induction of anaesthesia. Anaesthesia. 1978 Nov-Dec;33(10):906–912. [PubMed]
  • Mirakhur RK, Dundee JW, Jones CJ. Evaluation of the anticholinergic actions of glycopyrronium bromide. Br J Clin Pharmacol. 1978 Jan;5(1):77–84. [PMC free article] [PubMed]
  • Mirakhur RK, Jones CJ, Dundee JW. Effects of intravenous administration of glycopyrrolate and atropine in anaesthetised patients. Anaesthesia. 1981 Mar;36(3):277–281. [PubMed]

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