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J R Soc Med. 1981 August; 74(8): 601–604.
PMCID: PMC1438895

Multiple primary malignant neoplasia in three members of a family1


Three members of a family have presented in adult life with a succession of invasive malignancies. No known premalignant condition has been apparent in this group, and a limited study of immune competence has failed to reveal any abnormality. In spite of this there is strong evidence to suggest a so far undetected immunogenetic abnormality as the basis of this phenomenon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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  • Cooper MJ, Mackie CR, Skinner DB, Moossa AR. A reappraisal of the value of carcinoembryonic antigen in the management of patients with various neoplasms. Br J Surg. 1979 Feb;66(2):120–123. [PubMed]
  • Dellon AL, Chretien PB, Potvin C, Rogentine GN., Jr Multiple primary malignant neoplasms. A search for an immunogenetic basis. Arch Surg. 1975 Feb;110(2):156–160. [PubMed]
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  • Shankar PS. Case report. Five primary cancers in one patient. Postgrad Med. 1977 Feb;61(2):281–282. [PubMed]

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