PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1981 September; 74(9): 646–648.
PMCID: PMC1438857

Effect of inhaled alpha-blocker on airflow obstruction in asthma.

Abstract

A controlled study of the effect on airflow obstruction of 30 mg of the alpha-blocker thymoxamine given by inhalation is reported in 10 patients with chronic stable asthma. No significant change in peak expiratory flow rate was seen with either thymoxamine or placebo in any patient. Alpha-adrenergic receptors are therefore unlikely to contribute significantly to resting bronchomotor tone in chronic stable asthma.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (300K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Barnes PJ, Dollery CT, MacDermot J. Increased pulmonary alpha-adrenergic and reduced beta-adrenergic receptors in experimental asthma. Nature. 1980 Jun 19;285(5766):569–571. [PubMed]
  • Beil M, Brecht HM, Rasche B. Plasma catecholamines in exercise induced bronchoconstriction. Klin Wochenschr. 1977 Jun 15;55(12):577–581. [PubMed]
  • Bianco S, Griffin JP, Kamburoff PL, Prime FJ. The effect of thymoxamine on histamine induced bronchospasm in man. Br J Dis Chest. 1972 Jan;66(1):27–32. [PubMed]
  • Gaddie J, Legge JS, Petrie G, Palmer KN. The effect of an alpha-adrenergic receptor blocking drug on histamine sensitivity in bronchial asthma. Br J Dis Chest. 1972 Apr;66(2):141–146. [PubMed]
  • Henderson WR, Shelhamer JH, Reingold DB, Smith LJ, Evans R, 3rd, Kaliner M. Alpha-adrenergic hyper-responsiveness in asthma. N Engl J Med. 1979 Mar 22;300(12):642–647. [PubMed]
  • Kneussl MP, Richardson JB. Alpha-adrenergic receptors in human and canine tracheal and bronchial smooth muscle. J Appl Physiol Respir Environ Exerc Physiol. 1978 Aug;45(2):307–311. [PubMed]
  • Patel KR. The role of adrenoceptors in bronchial asthma. J R Coll Physicians Lond. 1979 Jul;13(3):165–171. [PubMed]
  • Patel KR, Kerr JW, MacDonald EB, MacKenzie AM. The effect of thymoxamine and cromolyn sodium on postexercise bronchoconstriction in asthma. J Allergy Clin Immunol. 1976 Apr;57(4):285–292. [PubMed]
  • Simonsson BG, Svedmyr N, Skoogh BE, Andersson R, Bergh NP. In vivo and in vitro studies on alpha-receptors in human airways. Potentiation with bacterial endotoxin. Scand J Respir Dis. 1972;53(4):227–236. [PubMed]
  • Sly RM, Heimlich EM, Busser RJ, Strick L. Exercise-induced bronchospasm: effect of adrenergic or cholinergic blockade. J Allergy. 1967 Aug;40(2):93–99. [PubMed]
  • Snashall PD, Boother FA, Sterling GM. The effect of alpha-adrenoreceptor stimulation on the airways of normal and asthmatic man. Clin Sci Mol Med. 1978 Mar;54(3):283–289. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press