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J R Soc Med. 1981 February; 74(2): 129–131.
PMCID: PMC1438653

Naloxone in the treatment of anorexia nervosa: effect on weight gain and lipolysis1


The effects of a constant intravenous infusion of naloxone in doses ranging from 3.2 to 6.4 mg/day were studied in a group of patients with anorexia nervosa. Patients showed a significantly greater weight gain during the infusion compared with the periods before and after naloxone. Plasma β-hydroxybutyrate and non-esterified fatty acid levels fell during the infusion. It is suggested that, in man, naloxone has an antilipolytic effect in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • DOLE VP, MEINERTZ H. Microdetermination of long-chain fatty acids in plasma and tissues. J Biol Chem. 1960 Sep;235:2595–2599. [PubMed]
  • Ghosh P, Mills IH, Moore R. The anti-ketotic effect of opiate receptor blockade by naloxone infusion in human diabetes [proceedings]. J Physiol. 1977 Oct;271(2):51P–52P. [PubMed]
  • Moore R, Mills IH. Serum T3 and T4 levels in patients with anorexia nervosa showing transient hyperthyroidism during weight gain. Clin Endocrinol (Oxf) 1979 May;10(5):443–449. [PubMed]
  • Schwandt P, Richter W, Wilkening J. In vitro lipolytic activity of porcine beta-endorphin not mediated by an opiate receptor. FEBS Lett. 1979 Apr 15;100(2):360–362. [PubMed]
  • WILLIAMSON DH, MELLANBY J, KREBS HA. Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood. Biochem J. 1962 Jan;82:90–96. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press