PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1982 September; 75(9): 709–714.
PMCID: PMC1438593

Faecal urobilinogen levels and pH of stools in population groups with different incidence of cancer of the colon, and their possible role in its aetiology.

Abstract

Mean faecal urobilinogen levels and the pH of stools were both found to be higher in subjects from a population group at high risk of developing cancer of the colon than in subjects matched for age, sex and socioeconomic status from a low-risk population group. An alkaline reaction of the colon contents seems to have a tumorigenic effect by a direct action on the mucus of the mucous cells. An acidic reaction, on the other hand, appears to be protective. These differences are dependent on the patterns of diet and manner of eating. Proper mastication of food, roughage, cellulose and vegetable fibre, and short-chain fatty acids of milk and fermented milk products in the diet appear to be protective.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (853K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Auerbach O, Garfinkel L, Hammond EC. Relation of smoking and age to findings in lung parenchyma: a microscopic study. Chest. 1974 Jan;65(1):29–35. [PubMed]
  • BALL PA, JAMES AH. The histological background to gastric ulcer. Lancet. 1961 Jun 24;1(7191):1365–1367. [PubMed]
  • Burkitt DP. Epidemiology of cancer of the colon and rectum. Cancer. 1971 Jul;28(1):3–13. [PubMed]
  • Cummings JH. Short chain fatty acids in the human colon. Gut. 1981 Sep;22(9):763–779. [PMC free article] [PubMed]
  • Dunham LJ, Muir CS, Hamner JE., 3rd Epithelial atypia in hamster cheek pouches treated repeatedly with calcium hydroxide. Br J Cancer. 1966 Sep;20(3):588–593. [PMC free article] [PubMed]
  • Dunham LJ, Sheets RH, Morton JF. Proliferative lesions in cheek pouch and esophagus of hamsters treated with plants from Curacao, Netherland Antilles. J Natl Cancer Inst. 1974 Nov;53(5):1259–1269. [PubMed]
  • DUPLESSIS DJ. PATHOGENESIS OF GASTRIC ULCERATION. Lancet. 1965 May 8;1(7393):974–978. [PubMed]
  • Eastwood MA, Kirkpatrick JR, Mitchell WD, Bone A, Hamilton T. Effects of dietary supplements of wheat bran and cellulose on faeces and bowel function. Br Med J. 1973 Nov 17;4(5889):392–394. [PMC free article] [PubMed]
  • Glober GA, Kamiyama S, Nomura A, Shimada A, Abba BC. Bowel transit-time and stool weight in populations with different colon-cancer risks. Lancet. 1977 Jul 16;2(8029):110–111. [PubMed]
  • Glinsky MJ, Smith RM, Spires HR, Davis CL. Measurement of volatile fatty acid production rates in the cecum of the pony. J Anim Sci. 1976 Jun;42(6):1465–1470. [PubMed]
  • Hirayama T. An epidemiological study of oral and pharyngeal cancer in Central and South-East Asia. Bull World Health Organ. 1966;34(1):41–69. [PubMed]
  • LAWSON HH. EFFECT OF DUODENAL CONTENTS ON THE GASTRIC MUCOSA UNDER EXPERIMENTAL CONDITIONS. Lancet. 1964 Feb 29;1(7331):469–472. [PubMed]
  • BABOURIS N, FLETCHER J, LENNARD-JONES JE. EFFECT OF DIFFERENT FOODS ON THE ACIDITY OF THE GASTRIC CONTENTS IN PATIENTS WITH DUODENAL ULCER. II. EFFECT OF VARYING THE SIZE AND FREQUENCY OF MEALS. Gut. 1965 Apr;6:118–120. [PMC free article] [PubMed]
  • Malhotra SL. Geographical distribution of gastrointestinal cancers in India with special reference to causation. Gut. 1967 Aug;8(4):361–372. [PMC free article] [PubMed]
  • Malhotra SL. Effect of diet on faecal and urine urobilinogen excretion and its possible relationship to the pathogenesis of peptic ulceration. Gut. 1968 Apr;9(2):183–186. [PMC free article] [PubMed]
  • Malhotra SL. Effect of patterns of eating and antacids on faecal urobilinogen excretion. Gut. 1968 Feb;9(1):38–41. [PMC free article] [PubMed]
  • Malhotra SL. Clues to the possible mode of action of cigarette smoke in the pathogenesis of lung cancer. J Indian Med Assoc. 1970 Oct 16;55(8):265–270. [PubMed]
  • Malhotra SL. A study of carcinoma of uterine cervix with special reference to its causation and prevention. Br J Cancer. 1971 Mar;25(1):62–71. [PMC free article] [PubMed]
  • Malhotra SL. New approaches to the causation and prevention of cancers of epithelial surfaces. Med Hypotheses. 1976 Nov-Dec;2(6):279–281. [PubMed]
  • Malhotra SL. Dietary factors in a study of cancer colon from Cancer Registry, with special reference to the role of saliva, milk and fermented milk products and vegetable fibre. Med Hypotheses. 1977 May-Jun;3(3):122–126. [PubMed]
  • Malhotra SL. Cholecystectomy and carcinoma of the colon. Lancet. 1981 Oct 24;2(8252):931–932. [PubMed]
  • MALHOTRA SL, SAIGAL ON, MODY GD. ROLE OF SALIVA IN THE AETIOLOGY OF PEPTIC ULCER. Br Med J. 1965 May 8;1(5444):1220–1222. [PMC free article] [PubMed]
  • Mudd DG, McKelvey ST, Norwood W, Elmore DT, Roy AD. Faecal bile acid concentration of patients with carcinoma or increased risk of carcinoma in the large bowel. Gut. 1980 Jul;21(7):587–590. [PMC free article] [PubMed]
  • Mudd DG, McKelvey ST, Sloan JM, Elmore DT. Faecal bile acid concentrations in patients at increased risk of large bowel cancer. Acta Gastroenterol Belg. 1978 May-Jun;41(5-6):241–244. [PubMed]
  • PAYMASTER JC. CANCER AND ITS DISTRIBUTION IN INDIA. Cancer. 1964 Aug;17:1026–1034. [PubMed]
  • Reddy BS, Sharma C, Darby L, Laakso K, Wynder EL. Metabolic epidemiology of large bowel cancer. Fecal mutagens in high- and low-risk population for colon cancer. A preliminary report. Mutat Res. 1980 Aug;72(3):511–522. [PubMed]
  • Reddy BS, Wynder EL. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer. 1977 Jun;39(6):2533–2539. [PubMed]
  • SHANTA V, KRISHNAMURTHI S. Further study in aetiology of carcinomas of the upper alimentary tract. Br J Cancer. 1963 Mar;17:8–23. [PMC free article] [PubMed]
  • Thornton JR. High colonic pH promotes colorectal cancer. Lancet. 1981 May 16;1(8229):1081–1083. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press