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J R Soc Med. 1982 November; 75(11): 888–892.
PMCID: PMC1438415

Chemotherapy of endodermal sinus tumour (yolk sac tumour) of the ovary: preliminary communication1


Eight patients presenting with endodermal sinus tumour of the ovary have been treated with combination chemotherapy using cisplatin, bleomycin and vinblastine (PVB). Complete remission occurred in 7 out of 8 cases, all of whom are alive and well 3 to 33 months later. These preliminary results are compared with our own past experience and recent reports in the literature. It is concluded that the PVB regimen is probably as effective in female germ cell tumours as it is in testicular teratoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Beilby JO, Horne CH, Milne GD, Parkinson C. Alpha-fetoprotein, alpha-1-antitrypsin, and transferrin in gonadal yolk-sac tumours. J Clin Pathol. 1979 May;32(5):455–461. [PMC free article] [PubMed]
  • Curry SL, Smith JP, Gallagher HS. Malignant teratoma of the ovary: prognostic factors and treatment. Am J Obstet Gynecol. 1978 Aug 15;131(8):845–849. [PubMed]
  • Duncan ID, Young JL. Endodermal sinus tumour of the ovary: serum alpha-fetoprotein levels before and after treatment and during pregnancy. Case report. Br J Obstet Gynaecol. 1980 Jun;87(6):535–538. [PubMed]
  • Einhorn LH, Donohue JP. Improved chemotherapy in disseminated testicular cancer. J Urol. 1977 Jan;117(1):65–69. [PubMed]
  • Huntington RW, Jr, Bullock WK. Yolk sac tumors of the ovary. Cancer. 1970 Jun;25(6):1357–1367. [PubMed]
  • Julian CG, Barrett JM, Richardson RL, Greco FA. Bleomycin, vinblastine, and cis-platinum in the treatment of advanced endodermal sinus tumor. Obstet Gynecol. 1980 Sep;56(3):396–401. [PubMed]
  • Kurman RJ, Norris HJ. Endodermal sinus tumor of the ovary: a clinical and pathologic analysis of 71 cases. Cancer. 1976 Dec;38(6):2404–2419. [PubMed]
  • Pierce GB, Bullock WK, Huntington RW., Jr Yolk sac tumors of the testis. Cancer. 1970 Mar;25(3):644–658. [PubMed]
  • TEILUM G. Endodermal sinus tumors of the ovary and testis. Comparative morphogenesis of the so-called mesoephroma ovarii (Schiller) and extraembryonic (yolk sac-allantoic) structures of the rat's placenta. Cancer. 1959 Nov-Dec;12:1092–1105. [PubMed]
  • TEOH TB, STEWARD JK, WILLIS RA. The distinctive adenocarcinoma of the infant's testis: an account of 15 cases. J Pathol Bacteriol. 1960 Jul;80:147–156. [PubMed]
  • Waldmann TA, McIntire KR. The use of a radioimmunoassay for alpha-fetoprotein in the diagnosis of malignancy. Cancer. 1974 Oct;34(4 Suppl):suppl–suppl:1515. [PubMed]
  • Wilkinson EJ, Friedrich EG, Hosty TA. Alpha-fetoprotein and endodermal sinus tumor of the ovary. Am J Obstet Gynecol. 1973 Jul 1;116(5):711–714. [PubMed]

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