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J R Soc Med. 1981 April; 74(4): 278, 279-282.
PMCID: PMC1438391

Clinical use of minoxidil (Loniten)1


The powerful peripheral vasodilator minoxidil, in a dose of 5–40 mg daily, controlled the previously refractory blood pressure in 45 out of 47 patients for periods up to fifty-seven months. The majority of the previous polypharmacy was withdrawn, leaving most of the patients taking a beta-blocking drug, minoxidil and a diuretic. Severe sodium retention leading to congestive cardiac failure necessitated the withdrawal of the drug in 3 patients. In one patient the drug was discontinued because of postural hypotension, and it was withdrawn in 2 female patients because of hirsutism. Five patients were removed from the trial as they were started on chronic maintenance haemodialysis or received a renal transplant. Significant glucose intolerance developed in one patient, requiring the addition of an oral hypoglycaemic agent. The 4 deaths that occurred were not directly related to treatment. Following the oral administration of 5 mg minoxidil, an obvious reduction in both the systolic and diastolic pressure was seen in two hours.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • DuCharme DW, Freyburger WA, Graham BE, Carlson RG. Pharmacologic properties of minoxidil: a new hypotensive agent. J Pharmacol Exp Ther. 1973 Mar;184(3):662–670. [PubMed]
  • Gottlieb TB, Thomas RC, Chidsey CA. Pharmacokinetic studies of minoxidil. Clin Pharmacol Ther. 1972 May-Jun;13(3):436–441. [PubMed]

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