Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1981 March; 74(3): 192–195.
PMCID: PMC1438271

Sleep apnoea in diabetic patients with autonomic neuropathy1


Breathing during sleep was monitored in 8 diabetic patients with objective evidence of autonomic neuropathy and in 8 diabetic patients without neuropathy. Thirty or more periods of apnoea lasting 10 seconds or longer during one night's sleep were demonstrated in 3 of the diabetic patients with autonomic neuropathy. Such apnoeic periods may be related to the high incidence of cardiorespiratory arrests reported in such patients, particularly in association with anaesthesia or pneumonia.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (696K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bannister R. Chronic autonomic failure with postural hypotension. Lancet. 1979 Aug 25;2(8139):404–406. [PubMed]
  • Block AJ, Boysen PG, Wynne JW, Hunt LA. Sleep apnea, hypopnea and oxygen desaturation in normal subjects. A strong male predominance. N Engl J Med. 1979 Mar 8;300(10):513–517. [PubMed]
  • Ewing DJ, Campbell IW, Clarke BF. Mortality in diabetic autonomic neuropathy. Lancet. 1976 Mar 20;1(7960):601–603. [PubMed]
  • Ewing DJ, Campbell IW, Murray A, Neilson JM, Clarke BF. Immediate heart-rate response to standing: simple test for autonomic neuropathy in diabetes. Br Med J. 1978 Jan 21;1(6106):145–147. [PMC free article] [PubMed]
  • Flenley DC. Methods and results of assessing the hypoxic ventilatory drive in patients and normal subjects. Bull Eur Physiopathol Respir. 1979;15 (Suppl):223–231. [PubMed]
  • Gale EA, Tattersall RB. Unrecognised nocturnal hypoglycaemia in insulin-treated diabetics. Lancet. 1979 May 19;1(8125):1049–1052. [PubMed]
  • Garcia-Buñuel L. Cardiorespiratory arrest in diabetic autonomic neuropathy. Lancet. 1978 Apr 29;1(8070):935–936. [PubMed]
  • Guilleminault C, Tilkian A, Dement WC. The sleep apnea syndromes. Annu Rev Med. 1976;27:465–484. [PubMed]
  • Gulleminault C, Lehrman AT, Forno L, Dement WC. Sleep apnoea syndrome: states of sleep and autonomic dysfunction. J Neurol Neurosurg Psychiatry. 1977 Jul;40(7):718–725. [PMC free article] [PubMed]
  • Lehrman KL, Guilleminault C, Schroeder JS, Tilkian A, Forno LN. Sleep apnea syndrome in a patient with Shy-Drager syndrome. Arch Intern Med. 1978 Feb;138(2):206–209. [PubMed]
  • Motta J, Guilleminault C, Schroeder JS, Dement WC. Tracheostomy and hemodynamic changes in sleep-inducing apnea. Ann Intern Med. 1978 Oct;89(4):454–458. [PubMed]
  • Orr WC, Martin RJ, Imes NK, Rogers RM, Stahl ML. Hypersomnolent and nonhypersomnolent patients with upper airway obstruction during sleep. Chest. 1979 Apr;75(4):418–422. [PubMed]
  • Page MM, Watkins PJ. Cardiorespiratory arrest and diabetic autonomic neuropathy. Lancet. 1978 Jan 7;1(8054):14–16. [PubMed]
  • Sharp JT, Druz WS, Foster JR, Wicks MS, Chokroverty S. Use of the respiratory magnetometer in diagnosis and classification of sleep apnea. Chest. 1980 Mar;77(3):350–353. [PubMed]
  • Srinivasan G, Sanders G. Cardiorespiratory arrest in diabetes. Lancet. 1978 Mar 4;1(8062):504–505. [PubMed]
  • Sundkvist G, Almér L0, Lilja B. Respiratory influence on heart rate in diabetes mellitus. Br Med J. 1979 Apr 7;1(6168):924–925. [PMC free article] [PubMed]
  • Tilkian AG, Guilleminault C, Schroeder JS, Lehrman KL, Simmons FB, Dement WC. Sleep-induced apnea syndrome. Prevalence of cardiac arrhythmias and their reversal after tracheostomy. Am J Med. 1977 Sep;63(3):348–358. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press