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J R Soc Med. 1980 December; 73(12): 842–844.
PMCID: PMC1438221

Effectiveness of amiodarone in resistant arrhythmias1


Amiodarone is used in the treatment of previously drug-resistant supraventricular and ventricular arrhythmias. We report our experience with amiodarone in 8 patients. Five patients had paroxysmal atrial flutter, one had paroxysmal atrial fibrillation, one had supraventricular tachycardia, and one ventricular tachycardia. Considerable improvement, both objectively and subjectively, was observed in all patients. Side effects were as follows: all patients had corneal microdeposits, one developed left bundle branch block which resolved on stopping amiodarone, and one reported constipation and abdominal pains. Six patients have been treated for 10–28 months; 3 developed tolerance at 4–14 months after the introduction of amiodarone therapy, but symptoms improved with increased dosage. It is important to watch for the development of tolerance to this drug.

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Selected References

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  • Chamberlain DA, Clark AN. Atrial fibrillation complicating Wolff-Parkinson-White syndrome treated with amiodarone. Br Med J. 1977 Dec 10;2(6101):1519–1520. [PMC free article] [PubMed]
  • Leak D, Eydt JN. Control of refractory cardiac arrhythmias with amiodarone. Arch Intern Med. 1979 Apr;139(4):425–428. [PubMed]
  • Rosenbaum MB, Chiale PA, Halpern MS, Nau GJ, Przybylski J, Levi RJ, Lázzari JO, Elizari MV. Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol. 1976 Dec;38(7):934–944. [PubMed]

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