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J R Soc Med. 1982 October; 75(10): 777–780.
PMCID: PMC1438110

Exchange transfusion in life-threatening sickling crises1


Five patients are reported with sickle cell syndromes (HbSS, HbSC and HbSthal) in whom rapid exchange transfusion led to resolution of life-threatening infarctive crises. The technique appears to be of value in the management of severe complications of sickle cell syndromes.

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Selected References

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  • Brody JI, Goldsmith MH, Park SK, Soltys HD. Symptomatic crises of sickle cell anemia treated by limited exchange transfusion. Ann Intern Med. 1970 Mar;72(3):327–330. [PubMed]
  • Buckle AE, Price TM, Whitmore DN. Exchange and simple transfusion in sickle-cell diseases in pregnancy. Postgrad Med J. 1969 Nov;45(529):722–725. [PMC free article] [PubMed]
  • Davis LR, Huehns ER, White JM. Survey of sickle-cell disease in England and Wales. Br Med J (Clin Res Ed) 1981 Dec 5;283(6305):1519–1521. [PMC free article] [PubMed]
  • EISENSTEIN MI, FRIEDMAN S, POSNER AC. Sickle-cell anemia in pregnancy; a review of the literature with additional case histories. Am J Obstet Gynecol. 1956 Sep;72(3):622–634. [PubMed]
  • Green M, Hall RJ, Huntsman RG, Lawson A, Pearson TC, Wheeler PC. Sickle cell crisis treated by exchange transfusion. Treatment of two patients with heterozygous sickle cell syndrome. JAMA. 1975 Mar 3;231(9):948–950. [PubMed]
  • Green RL, Huntsman RG, Serjeant GR. The sickle-cell and altitude. Br Med J. 1971 Dec 4;4(5787):593–595. [PMC free article] [PubMed]
  • Krupp PJ, Jr, Barclay DL, Roeling WM, Wegener G. Maternal mortality. A 20 year study of Tulane Department of Obstetrics and Gynecology at Charity Hospital. Obstet Gynecol. 1970 May;35(5):823–829. [PubMed]
  • Macleod JA. Exchange transfusion in a 7-year-old girl with sickle cell anaemia as preparation for adenoidectomy. Proc R Soc Med. 1969 Nov;62(11 Pt 1):1095–1096. [PMC free article] [PubMed]
  • Perkins RP. Inherited disorders of hemoglobin synthesis and pregnancy. Am J Obstet Gynecol. 1971 Sep;111(1):120–159. [PubMed]
  • Ricks P., Jr Further experience with exchange transfusion in sickle cell anemia and pregnancy. Am J Obstet Gynecol. 1968 Apr 15;100(8):1087–1091. [PubMed]
  • Serjeant GR, Ashcroft MT, Serjeant BE. The clinical features of haemoglobin SC disease in Jamaica. Br J Haematol. 1973 Apr;24(4):491–501. [PubMed]
  • Sheehy TW, Plumb VJ. Treatment of sickle cell disease. Arch Intern Med. 1977 Jun;137(6):779–782. [PubMed]
  • Trubowitz S. The management of sickle cell anemia. Med Clin North Am. 1976 Sep;60(5):933–944. [PubMed]

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