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J R Soc Med. 1980 October; 73(10): 708–712.
PMCID: PMC1438105

Value of xenografts in the investigation of prostatic function: preliminary communication1


Two of 33 prostatic tumour xenografts were established and passaged. Testosterone supplementation did not improve tumour take rates. The histological grade of the parent tumour was the principal factor affecting xenograft survival. Preliminary studies on established tumour xenografts suggest that their value lies in the study of tumour biology, and that they have no direct therapeutic application at present.

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Selected References

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  • GREENE HSN. The significance of the heterologous transplantability of human cancer. Cancer. 1952 Jan;5(1):24–44. [PubMed]
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  • Povlsen CO, Rygaard J. Heterotransplantation of human adenocarcinomas of the colon and rectum to the mouse mutant Nude. A study of nine consecutive transplantations. Acta Pathol Microbiol Scand A. 1971;79(2):159–169. [PubMed]
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  • Sandberg AA, Gaunt R. Model systems for studies of prostatic cancer. Semin Oncol. 1976 Jun;3(2):177–187. [PubMed]
  • Sato G, Desmond W, Kelly F. Human prostatic tumors in conditioned animals and culture. Cancer Chemother Rep. 1975 Jan-Feb;59(1):47–49. [PubMed]
  • Williams G, Ghanadian R, Papadopoulos AS, Castro JE. Hormonal environment of immunosuppressed mice. Br J Cancer. 1978 Jan;37(1):123–125. [PMC free article] [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press