PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1980 October; 73(10): 708–712.
PMCID: PMC1438105

Value of xenografts in the investigation of prostatic function: preliminary communication1

Abstract

Two of 33 prostatic tumour xenografts were established and passaged. Testosterone supplementation did not improve tumour take rates. The histological grade of the parent tumour was the principal factor affecting xenograft survival. Preliminary studies on established tumour xenografts suggest that their value lies in the study of tumour biology, and that they have no direct therapeutic application at present.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (486K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Davies AJ, Carter RL, Leuchars E, Wallis V, Koller PC. The morphology of immune reactions in normal, thymectomized and reconstituted mice. I. The response to sheep erythrocytes. Immunology. 1969 Jan;16(1):57–69. [PubMed]
  • Davies AJ, Leuchars E, Wallis V, Koller PC. The mitotic response of thymus-derived cells to antigenic stimulus. Transplantation. 1966 Jul;4(4):438–451. [PubMed]
  • GREENE HSN. The significance of the heterologous transplantability of human cancer. Cancer. 1952 Jan;5(1):24–44. [PubMed]
  • Mickey DD, Stone KR, Wunderli H, Mickey GH, Vollmer RT, Paulson DF. Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice. Cancer Res. 1977 Nov;37(11):4049–4058. [PubMed]
  • Schroeder FH, Okada K, Jellinghaus W, Wullstein HK, Heinemeyer HM. Human prostatic adenoma and carcinoma. Transplantation of cultured cells and primary tissue fragments in "nude" mice. Invest Urol. 1976 May;13(6):395–403. [PubMed]
  • Povlsen CO, Rygaard J. Heterotransplantation of human adenocarcinomas of the colon and rectum to the mouse mutant Nude. A study of nine consecutive transplantations. Acta Pathol Microbiol Scand A. 1971;79(2):159–169. [PubMed]
  • Rivenson A, Silverman J. The prostatic carcinoma in laboratory animals: a bibliographic survey from 1900 to 1977. Invest Urol. 1979 May;16(6):468–472. [PubMed]
  • Sandberg AA, Gaunt R. Model systems for studies of prostatic cancer. Semin Oncol. 1976 Jun;3(2):177–187. [PubMed]
  • Sato G, Desmond W, Kelly F. Human prostatic tumors in conditioned animals and culture. Cancer Chemother Rep. 1975 Jan-Feb;59(1):47–49. [PubMed]
  • Williams G, Ghanadian R, Papadopoulos AS, Castro JE. Hormonal environment of immunosuppressed mice. Br J Cancer. 1978 Jan;37(1):123–125. [PMC free article] [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press