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J R Soc Med. 1980 October; 73(10): 727–730.
PMCID: PMC1438092

Comparison of the effects of atropine and glycopyrrolate on various end-organs1


Atropine and glycopyrrolate (glycopyrronium bromide), a quaternary ammonium drug, were evaluated in volunteers following intramuscular administration with respect to effects on various end-organs with cholinergic innervation. Glycopyrrolate appears to be five to six times more potent than atropine in its antisialogogue effect and also exhibits a selective, though prolonged, effect on salivary secretion and sweat gland activity. It has minimal cardiovascular, ocular and central nervous system effects.

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Selected References

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  • WYANT GM, DOBKIN AB. Antisialogogue drugs in man; comparison of atropine, scopolamine (1-hyoscine) and 1-hyoscyamine (bellafoline). Anaesthesia. 1957 Apr;12(2):203–214. [PubMed]
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