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J R Soc Med. 1982 June; 75(6): 394–398.
PMCID: PMC1437966

Expanding options in radiation oncology: neutron beam therapy.


Twelve years' experience with neutron beam therapy in Britain, the USA, Europe and Japan shows that local control is achievable in late-stage epidermoid cancer somewhat more frequently than with conventional radiotherapy. Tumours reputed to be radioresistant (salivary gland, bladder, rectosigmoid, melanoma, bone and soft-tissue sarcomas) have proved to be particularly responsive to neutrons. Pilot studies in brain and pancreatic tumours suggest promising new approaches to management of cancer in these sites. The availability of neutron therapy in the clinical environment opens new prospects for irradiation of 'radioresistant' tumours, permits more conservative cancer surgery, expands the use of elective chemotherapy and provides a wider range of options for cancer patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Battermann JJ, Breur K. Results of fast neutron teletherapy for locally advanced head and neck tumors. Int J Radiat Oncol Biol Phys. 1981 Aug;7(8):1045–1050. [PubMed]
  • Cohen L, Awschalom M. Fast neutron radiation therapy. Annu Rev Biophys Bioeng. 1982;11:359–390. [PubMed]
  • Cohen L, Hendrickson F, Mansell J, Awschalom M, Hrejsa A, Kaul R, Rosenberg I. Late reactions and complications in patients treated with high energy neutrons p (66MeV)be(49MeV). Int J Radiat Oncol Biol Phys. 1981 Feb;7(2):179–184. [PubMed]
  • Kaul R, Cohen L, Hendrickson F, Awschalom M, Hrejsa AF, Rosenberg I. Pancreatic carcinoma: results with fast neutron therapy. Int J Radiat Oncol Biol Phys. 1981 Feb;7(2):173–178. [PubMed]
  • Kaul R, Hendrickson F, Cohen L, Rosenberg I, Ten Haken R, Awschalom M, Mansell J. Fast neutrons in the treatment of salivary gland tumors. Int J Radiat Oncol Biol Phys. 1981 Dec;7(12):1667–1671. [PubMed]
  • Maor MH, Hussey DH, Fletcher GH, Jesse RH. Fast neutron therapy for locally advanced head and neck tumors. Int J Radiat Oncol Biol Phys. 1981 Feb;7(2):155–163. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press