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J R Soc Med. 1980 August; 73(8): 567–569.
PMCID: PMC1437818

Study of antibody-coated fungi in patients with funguria and suspected disseminated fungal infections or primary fungal pyelonephritis1


The direct immunofluorescence method for the detection of antibody-coated bacteria in urine sediments has been used by investigators to distinguish invasive bacterial disease of the renal parenchyma from noninvasive bladder bacteriuria. The purpose of the present investigation was to test the usefulness of the demonstration of urinary fungal immunoglobulins and complement in distinguishing patients with fungal cystitis from those with suspected disseminated fungal disease. Twenty-one patients with microscopic funguria were suspected clinically of having disseminated fungal infection. Urine specimens from these patients were tested for the presence of antibody- and complement-coated fungi by direct immunofluorescence with the use of specific goat antisera to human immunoglobulins and complement. No unexpected frequencies of combinations of urinary yeast staining by specific antibody were noted. Urine specimens demonstrating funguria from 12 patients with uncomplicated illnesses were also examined for the presence of antibody- and complement-coated fungi; no unexpected frequencies of combinations of urinary yeast staining were noted in this group and no differences in frequencies of specific antibody staining were noted when compared with results in patients with suspected invasive fungal disease. Thus, no difference in the occurrence of specific antibody or complement adsorbed to urinary yeasts was observed between patients suspected of having invasive fungal disease and a small group of control patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Everett ED, Eickhoff TC, Ehret JM. Immunofluorescence of yeast in urine. J Clin Microbiol. 1976 Aug;2(2):142–143. [PMC free article] [PubMed]
  • Glew RH, Buckley HR, Rosen HM, Moellering RC, Jr, Fischer JE. Serologic tests in the diagnosis of systemic candidiasis. Enhanced diagnostic accuracy with crossed immunoelectrophoreses. Am J Med. 1978 Apr;64(4):586–591. [PubMed]
  • Harding SA, Merz WG. Evaluation of antibody coating of yeasts in urine as an indicator of the site of urinary tract infection. J Clin Microbiol. 1975 Sep;2(3):222–225. [PMC free article] [PubMed]
  • Jones SR, Smith JW, Sanford JP. Localization of urinary-tract infections by detection of antibody-coated bacteria in urine sediment. N Engl J Med. 1974 Mar 14;290(11):591–593. [PubMed]
  • Kozinn PJ, Taschdjian CL, Goldberg PK, Protzmann WP, MacKenzie DW, Remington JS, Anderson S, Seelig MS. Efficiency of serologic tests in the diagnosis of systemic candidiasis. Am J Clin Pathol. 1978 Dec;70(6):893–898. [PubMed]
  • Lehmann JD, Smith JW, Miller TE, Barnett JA, Sanford JP. Local immune response in experimental pyelonephritis. J Clin Invest. 1969 Nov;47(11):2541–2550. [PMC free article] [PubMed]
  • Pearsall NN, Sherris JC. The demonstration of specific urinary anti-bodies in urinary tract infections caused by Gram-negative bacilli. J Pathol Bacteriol. 1966 Apr;91(2):589–595. [PubMed]
  • Thomas VL, Harris RE, Gilstrap LC, 3rd, Shelokov A. Antibody-coated bacteria in the urine of obstetrical patients with acute pyelonephritis. J Infect Dis. 1975 May;131 (Suppl):S57–S61. [PubMed]
  • Thomas V, Shelokov A, Forland M. Antibody-coated bacteria in the urine and the site of urinary-tract infection. N Engl J Med. 1974 Mar 14;290(11):588–590. [PubMed]
  • Weiner MH, Yount WJ. Mannan antigenemia in the diagnosis of invasive Candida infections. J Clin Invest. 1976 Nov;58(5):1045–1053. [PMC free article] [PubMed]

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