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J R Soc Med. 1982 May; 75(5): 323–326.
PMCID: PMC1437798

Ranitidine and duodenal ulceration: a short-term and maintenance study1


Forty-eight patients successfully completed a six-week, double blind, placebo controlled trial of ranitidine hydrochloride 200mg twice daily for active duodenal ulceration. Following endoscopy 68% of the patients taking ranitidine had healed, compared to 35% of those who were taking placebo. Nineteen of the patients who had not healed then took a further six weeks of open active treatment; of these, 14 were successfully treated. Thirty-one of the patients who had healed duodenal ulcers then took ranitidine hydrochloride 100mg at night as a maintenance treatment for one year: 71% remained endoscopically and symptomatically in remission. No serious side effects were encountered.

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Selected References

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  • Berstad A, Kett K, Aadland E, Carlsen E, Frislid K, Saxhaug K, Kruse-Jensen A. Treatment of duodenal ulcer with ranitidine, a new histamine H2-receptor antagonist. Scand J Gastroenterol. 1980;15(5):637–639. [PubMed]
  • Kett K, Aadland E, Berstad A. Inhibition of gastric secretion in man with a new H2-receptor antagonist, ranitidine. Scand J Gastroenterol. 1980;15(2):249–251. [PubMed]
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  • Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. [PMC free article] [PubMed]
  • Walt RP, Male PJ, Rawlings J, Hunt RH, Milton-Thompson GJ, Misiewicz JJ. Comparison of the effects of ranitidine, cimetidine and placebo on the 24 hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer. Gut. 1981 Jan;22(1):49–54. [PMC free article] [PubMed]
  • Walt RP, Trotman IF, Frost R, Golding PL, Shepherd TH, Rawlings J, Hunt RH, Colin-Jones D, Milton-Thompson GJ, Misiewicz JJ. Comparison of twice-daily ranitidine with standard cimetidine treatment of duodenal ulcer. Gut. 1981 Apr;22(4):319–322. [PMC free article] [PubMed]

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