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J R Soc Med. 1982 May; 75(5): 346–350.
PMCID: PMC1437779

Lymphadenopathy mimicking lymphoma associated with cryoglobulinaemia and arteritis1


Two patients are described with polyclonal IgG cryoglobulinaemia and necrotizing arteritis who developed severe lymphadenopathy which clinically mimicked malignant lymphoma. Histological studies demonstrated that the lymphadenopathy resulted from a pseudolymphomatous reaction associated with vascular damage.

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Selected References

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  • Brouet JC, Clauvel JP, Danon F, Klein M, Seligmann M. Biologic and clinical significance of cryoglobulins. A report of 86 cases. Am J Med. 1974 Nov;57(5):775–788. [PubMed]
  • Cream JJ. Cryoglobulins in vasculitis. Clin Exp Immunol. 1972 Jan;10(1):117–126. [PubMed]
  • Gorevic PD, Kassab HJ, Levo Y, Kohn R, Meltzer M, Prose P, Franklin EC. Mixed cryoglobulinemia: clinical aspects and long-term follow-up of 40 patients. Am J Med. 1980 Aug;69(2):287–308. [PubMed]
  • Grey HM, Kohler PF. Cryoimmunoglobulins. Semin Hematol. 1973 Apr;10(2):87–112. [PubMed]
  • Schimmer BM, Bloch KJ. Mixed IgM-IgG cryoglobulinemia terminating in polyarteritis nodosa. J Rheumatol. 1975 Jun;2(2):241–250. [PubMed]
  • Soter NA, Austen KF, Gigli I. Urticaria and arthralgias as manifestations of necrotizing angiitis (vasculitis). J Invest Dermatol. 1974 Dec;63(6):485–490. [PubMed]
  • Tanaka N, Sekimoto K, Naoe S. Kawasaki disease. Relationship with infantile periarteritis nodosa. Arch Pathol Lab Med. 1976 Feb;100(2):81–86. [PubMed]

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