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J R Soc Med. 1982 May; 75(5): 336–340.
PMCID: PMC1437777

Use of the muscle relaxant atracurium in anephric patients: preliminary communication1


Atracurium is a new, non-depolarizing muscle relaxant which rapidly breaks down in vivo and appears to require neither renal nor hepatic function for its elimination. As the commonly used non-depolarizing muscle relaxants carry the risk of prolonged effect when used in anephric patients, atracurium appears to have special promise in this situation. A preliminary account of the successful use of the relaxant in 20 anephric patients is recorded and evidence presented that atracurium is, indeed, a suitable agent for use in patients with renal failure.

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Selected References

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  • Ali HH, Savarese JJ. Monitoring of neuromuscular function. Anesthesiology. 1976 Aug;45(2):216–249. [PubMed]
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  • Fahey MR, Morris RB, Miller RD, Nguyen TL, Upton RA. Pharmacokinetics of Org NC45 (norcuron) in patients with and without renal failure. Br J Anaesth. 1981 Oct;53(10):1049–1053. [PubMed]
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  • Payne JP, Hughes R. Evaluation of atracurium in anaesthetized man. Br J Anaesth. 1981 Jan;53(1):45–54. [PubMed]
  • Riordan DD, Gilbertson AA. Prolonged curarization in a patient with renal failure. Case report. Br J Anaesth. 1971 May;43(5):506–508. [PubMed]
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  • Stovner J, Lund I. The muscle relaxants and their antagonists. Br J Anaesth. 1970 Mar;42(3):235–248. [PubMed]

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