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J R Soc Med. 1980 July; 73(7): 482–491.
PMCID: PMC1437682

Neuropeptides and monoaminergic neurotransmitters: their relation to pain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Akil H, Liebeskind JC. Monoaminergic mechanisms of stimulation-produced analgesia. Brain Res. 1975 Aug 29;94(2):279–296. [PubMed]
  • Akil H, Richardson DE, Barchas JD, Li CH. Appearance of beta-endorphin-like immunoreactivity in human ventricular cerebrospinal fluid upon analgesic electrical stimulation. Proc Natl Acad Sci U S A. 1978 Oct;75(10):5170–5172. [PubMed]
  • Basbaum AI, Clanton CH, Fields HL. Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems. J Comp Neurol. 1978 Mar 15;178(2):209–224. [PubMed]
  • Beall JE, Martin RF, Applebaum AE, Willis WD. Inhibition of primate spinothalamic tract neurons by stimulation in the region of the nucleus raphe mahnus. Brain Res. 1976 Sep 17;114(2):328–333. [PubMed]
  • Bennett JP, Jr, Snyder SH. Angiotensin II binding to mammalian brain membranes. J Biol Chem. 1976 Dec 10;251(23):7423–7430. [PubMed]
  • Berelowitz M, Hudson A, Pimstone B, Kronheim S, Bennet GW. Subcellular localization of growth hormone release inhibiting hormone in rat hypothalamus, cerebral cortex, striatum and thalamus. J Neurochem. 1978 Sep;31(3):751–753. [PubMed]
  • Bloom FE, Rossier J, Battenberg EL, Bayon A, French E, Henriksen SJ, Siggins GR, Segal D, Browne R, Ling N, et al. beta-endorphin: cellular localization, electrophysiological and behavioral effects. Adv Biochem Psychopharmacol. 1978;18:89–109. [PubMed]
  • Breglio V, Anderson DC, Merrill HK. Alteration in footschock threshold by low-level septal brain stimulation. Physiol Behav. 1970 Jul;5(7):715–719. [PubMed]
  • Brown M, Vale W. Central nervous system effects of hypothalamic peptides. Endocrinology. 1975 May;96(5):1333–1336. [PubMed]
  • CARLSSON A, FALCK B, FUXE K, HILLARP NA. CELLULAR LOCALIZATION OF MONOAMINES IN THE SPINAL CORD. Acta Physiol Scand. 1964 Jan-Feb;60:112–119. [PubMed]
  • Catlin DH, Hui KK, Loh HH, Li CH. Pharmacologic activity of beta-endorphin in man. Commun Psychopharmacol. 1977;1(5):493–500. [PubMed]
  • Chang MM, Leeman SE. Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P. J Biol Chem. 1970 Sep 25;245(18):4784–4790. [PubMed]
  • Chan-Palay V, Jonsson G, Palay SL. Serotonin and substance P coexist i, neurons of the rat's central nervous system. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1582–1586. [PubMed]
  • Clineschmidt BV, Anderson EG. The blockade of bulbospinal inhibition by 5-hydroxytryptamine antagonists. Exp Brain Res. 1970;11(2):175–186. [PubMed]
  • Clineschmidt BV, McGuffin JC. Neurotensin administered intracisternally inhibits responsiveness of mice to noxious stimuli. Eur J Pharmacol. 1977 Dec 15;46(4):395–396. [PubMed]
  • COONS AH. Fluorescent antibody methods. Gen Cytochem Methods. 1958;1:399–422. [PubMed]
  • Cuello AC, Jessell TM, Kanazawa I, Iversen LL. Substance P: localization in synaptic vesicles in rat central nervous system. J Neurochem. 1977 Oct;29(4):747–751. [PubMed]
  • Cuello AC, Kanazawa I. The distribution of substance P immunoreactive fibers in the rat central nervous system. J Comp Neurol. 1978 Mar 1;178(1):129–156. [PubMed]
  • FUXE K. EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM. Acta Physiol Scand Suppl. 1965:SUPPL 247–247:37+. [PubMed]
  • Dodd J, Kelly S. Is somatostatin an excitatory transmitter in the hippocampus? Nature. 1978 Jun 22;273(5664):674–675. [PubMed]
  • Duggan AW, Hall JG, Headley PM. Enkephalins and dorsal horn neurones of the cat: effects on responses to noxious and innocuous skin stimuli. Br J Pharmacol. 1977 Nov;61(3):399–408. [PMC free article] [PubMed]
  • Engberg I, Lundberg A, Ryall RW. Is the tonic decerebrate inhibition of reflex paths mediated by monoaminergic pathways? Acta Physiol Scand. 1968 Jan-Feb;72(1):123–133. [PubMed]
  • Engberg I, Lundberg A, Ryall RW. Reticulospinal inhibition of transmission in reflex pathways. J Physiol. 1968 Jan;194(1):201–223. [PubMed]
  • Engberg I, Lundberg A, Ryall RW. Reticulospinal inhibition of interneurones. J Physiol. 1968 Jan;194(1):225–236. [PubMed]
  • Fields HL, Basbaum AI, Clanton CH, Anderson SD. Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons. Brain Res. 1977 May 13;126(3):441–453. [PubMed]
  • Fields HL, Basbaum AI. Brainstem control of spinal pain-transmission neurons. Annu Rev Physiol. 1978;40:217–248. [PubMed]
  • Fischer-Ferraro C, Nahmod VE, Goldstein DJ, Finkielman S. Angiotensin and renin in rat and dog brain. J Exp Med. 1971 Feb 1;133(2):353–361. [PMC free article] [PubMed]
  • Frederickson RC, Burgis V, Harrell CE, Edwards JD. Dual actions of substance P on nociception: possible role of endogenous opioids. Science. 1978 Mar 24;199(4335):1359–1362. [PubMed]
  • Gol A. Relief of pain by electrical stimulation of the septal area. J Neurol Sci. 1967 Jul-Aug;5(1):115–120. [PubMed]
  • Henry JL. Effects of substance P on functionally identified units in cat spinal cord. Brain Res. 1976 Sep 24;114(3):439–451. [PubMed]
  • Henry JL, Krnjevíc K, Morris ME. Substance P and spinal neurones. Can J Physiol Pharmacol. 1975 Jun;53(3):423–432. [PubMed]
  • Hökfelt T, Efendic S, Johansson O, Luft R, Arimura A. Immunohistochemical localization of somatostatin (growth hormone release-inhibiting factor) in the guinea pig brain. Brain Res. 1974 Nov 8;80(1):165–169. [PubMed]
  • Hökfelt T, Elde R, Johansson O, Luft R, Nilsson G, Arimura A. Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat. Neuroscience. 1976;1(2):131–136. [PubMed]
  • Hökfelt T, Ljungdahl A, Steinbusch H, Verhofstad A, Nilsson G, Brodin E, Pernow B, Goldstein M. Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system. Neuroscience. 1978;3(6):517–538. [PubMed]
  • Hökfelt T, Ljungdahl A, Terenius L, Elde R, Nilsson G. Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P. Proc Natl Acad Sci U S A. 1977 Jul;74(7):3081–3085. [PubMed]
  • Hosobuchi Y, Adams JE, Rutkin B. Chronic thalamic stimulation for the control of facial anesthesia dolorosa. Arch Neurol. 1973 Sep;29(3):158–161. [PubMed]
  • Hughes J. Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine. Brain Res. 1975 May 2;88(2):295–308. [PubMed]
  • Hughes J, Smith TW, Kosterlitz HW, Fothergill LA, Morgan BA, Morris HR. Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature. 1975 Dec 18;258(5536):577–580. [PubMed]
  • Iversen LL, Iversen SD, Bloom F, Douglas C, Brown M, Vale W. Calcium-dependent release of somatostatin and neurotensin from rat brain in vitro. Nature. 1978 May 11;273(5658):161–163. [PubMed]
  • Innis RB, Corrêa FM, Uhl GR, Schneider B, Snyder SH. Cholecystokinin octapeptide-like immunoreactivity: histochemical localization in rat brain. Proc Natl Acad Sci U S A. 1979 Jan;76(1):521–525. [PubMed]
  • Jessell TM, Iversen LL. Opiate analgesics inhibit substance P release from rat trigeminal nucleus. Nature. 1977 Aug 11;268(5620):549–551. [PubMed]
  • Jessell TM, Iversen LL, Cuello AC. Capsaicin-induced depletion of substance P from primary sensory neurones. Brain Res. 1978 Aug 18;152(1):183–188. [PubMed]
  • Jordan LM, Kenshalo DR, Jr, Martin RF, Haber LH, Willis WD. Depression of primate spinothalamic tract neurons by iontophoretic application of 5-hydroxytryptamine. Pain. 1978 Aug;5(2):135–142. [PubMed]
  • Jørgensen A, Fog R, Veilis B. Synthetic enkephalin analogue in treatment of schizophrenia. Lancet. 1979 Apr 28;1(8122):935–935. [PubMed]
  • Kitabgi P, Carraway R, Van Rietschoten J, Granier C, Morgat JL, Menez A, Leeman S, Freychet P. Neurotensin: specific binding to synaptic membranes from rat brain. Proc Natl Acad Sci U S A. 1977 May;74(5):1846–1850. [PubMed]
  • Kobayashi RM, Brown M, Vale W. Regional distribution of neurotensin and somatostatin in rat brain. Brain Res. 1977 May 13;126(3):584–588. [PubMed]
  • Ljungdahl A, Hökfelt T, Nilsson G, Goldstein M. Distribution of substance P-like immunoreactivity in the central nervous system of the rat--II. Light microscopic localization in relation to catecholamine-containing neurons. Neuroscience. 1978;3(10):945–976. [PubMed]
  • Mayer DJ, Wolfle TL, Akil H, Carder B, Liebeskind JC. Analgesia from electrical stimulation in the brainstem of the rat. Science. 1971 Dec 24;174(4016):1351–1354. [PubMed]
  • Mohrland JS, Gebhart GF. Substance P-induced analgesia in the rat. Brain Res. 1979 Aug 10;171(3):556–559. [PubMed]
  • Moriarty GC. Adenohypophysis: ultrastructural cytochemistry. A review. J Histochem Cytochem. 1973 Oct;21(10):855–894. [PubMed]
  • Mroz EA, Leeman SE. Substance P. Vitam Horm. 1977;35:209–281. [PubMed]
  • Mudge AW, Leeman SE, Fischbach GD. Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration. Proc Natl Acad Sci U S A. 1979 Jan;76(1):526–530. [PubMed]
  • Toyama K, Matsunami K. Convergence of specific visual and commissural impulses upon inhibitory interneurones in cats visual cortex. Neuroscience. 1976;1(2):107–112. [PubMed]
  • Oliveras JL, Guilbaud G, Besson JM. A map of serotoninergic structures involved in stimulation producing analgesia in unrestrained freely moving cats. Brain Res. 1979 Mar 23;164:317–322. [PubMed]
  • Randić M, Miletić V. Depressant actions of methionine-enkephalin and somatostatin in cat dorsal horn neurones activated by noxious stimuli. Brain Res. 1978 Aug 18;152(1):196–202. [PubMed]
  • Rehfeld JF, Goltermann N, Larsson LI, Emson PM, Lee CM. Gastrin and cholecystokinin in central and peripheral neurons. Fed Proc. 1979 Aug;38(9):2325–2329. [PubMed]
  • Renaud LP, Martin JB, Brazeau P. Depressant action of TRH, LH-RH and somatostatin on activity of central neurones. Nature. 1975 May 15;255(5505):233–235. [PubMed]
  • Reynolds DV. Surgery in the rat during electrical analgesia induced by focal brain stimulation. Science. 1969 Apr 25;164(3878):444–445. [PubMed]
  • Richardson DE, Akil H. Long term results of periventricular gray self-stimulation. Neurosurgery. 1977 Sep-Oct;1(2):199–202. [PubMed]
  • Roemer D, Buescher HH, Hill RC, Pless J, Bauer W, Cardinaux F, Closse A, Hauser D, Huguenin R. A synthetic enkephalin analogue with prolonged parenteral and oral analgesic activity. Nature. 1977 Aug 11;268(5620):547–549. [PubMed]
  • RYALL RW. THE SUBCELLULAR DISTRIBUTIONS OF ACETYLCHOLINE, SUBSTANCE P, 5-HYDROXYTRYPTAMINE, GAMMA-AMINOBUTYRIC ACID AND GLUTAMIC ACID IN BRAIN HOMOGENATES. J Neurochem. 1964 Mar;11:131–145. [PubMed]
  • Said SI, Mutt V. Polypeptide with broad biological activity: isolation from small intestine. Science. 1970 Sep 18;169(3951):1217–1218. [PubMed]
  • Sar M, Stumpf WE, Miller RJ, Chang KJ, Cuatrecasas P. Immunohistochemical localization of enkephalin in rat brain and spinal cord. J Comp Neurol. 1978 Nov 1;182(1):17–37. [PubMed]
  • Sasa M, Munekiyo K, Ikeda H, Takaori S. Noradrenaline-mediated inhibition by locus coeruleus of spinal trigeminal neurons. Brain Res. 1974 Nov 22;80(3):443–460. [PubMed]
  • Schmidek HH, Fohanno D, Ervin FR, Sweet WH. Pain threshold alterations by brain stimulation in the monkey. J Neurosurg. 1971 Dec;35(6):715–722. [PubMed]
  • Simantov R, Kuhar MJ, Pasternak GW, Snyder SH. The regional distribution of a morphine-like factors enkephalin in monkey brain. Brain Res. 1976 Apr 16;106(1):189–197. [PubMed]
  • Simantov R, Kuhar MJ, Uhl GR, Snyder SH. Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system. Proc Natl Acad Sci U S A. 1977 May;74(5):2167–2171. [PubMed]
  • Simantov R, Snowman AM, Snyder SH. A morphine-like factor 'enkephalin' in rat brain: subcellular localization. Brain Res. 1976 May 14;107(3):650–657. [PubMed]
  • Straus E, Muller JE, Choi HS, Paronetto F, Yalow RS. Immunohistochemical localization in rabbit brain of a peptide resembling the COOH-terminal octapeptide of cholecystokinin. Proc Natl Acad Sci U S A. 1977 Jul;74(7):3033–3034. [PubMed]
  • Takagi H, Shiomi H, Kuraishi Y, Fukui K, Ueda H. Pain and the bulbospinal noradrenergic system: pain-induced increase in normetanephrine content in the spinal cord and its modification by morphine. Eur J Pharmacol. 1979 Feb 15;54(1-2):99–107. [PubMed]
  • Uhl GR, Goodman RR, Kuhar MJ, Snyder SH. Enkephalin and neurotensin: immunohistochemical localization and identification of an amygdalofugal pathway. Adv Biochem Psychopharmacol. 1978;18:71–87. [PubMed]
  • Uhl GR, Snyder SH. Regional and subcellular distributions of brain neurotensin. Life Sci. 1976 Dec 15;19(12):1827–1832. [PubMed]
  • Vale W, Rivier C, Brown M. Regulatory peptides of the hypothalamus. Annu Rev Physiol. 1977;39:473–527. [PubMed]
  • von Graffenried B, del Pozo E, Roubicek J, Krebs E, Poldinger W, Burmeister P, Kerp L. Effects of the synthetic enkephalin analogue FK 33-824 in man. Nature. 1978 Apr 20;272(5655):729–730. [PubMed]
  • Watson SJ, Akil H, Richard CW, 3rd, Barchas JD. Evidence for two separate opiate peptide neuronal systems. Nature. 1978 Sep 21;275(5677):226–228. [PubMed]
  • Watson SJ, Barchas JD, Li CH. beta-Lipotropin: localization of cells and axons in rat brain by immunocytochemistry. Proc Natl Acad Sci U S A. 1977 Nov;74(11):5155–5158. [PubMed]
  • Willis WD, Haber LH, Martin RF. Inhibition of spinothalamic tract cells and interneurons by brain stem stimulation in the monkey. J Neurophysiol. 1977 Jul;40(4):968–981. [PubMed]
  • Yaksh TL. Direct evidence that spinal serotonin and noradrenaline terminals mediate the spinal antinociceptive effects of morphine in the periaqueductal gray. Brain Res. 1979 Jan 5;160(1):180–185. [PubMed]

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