PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1982 April; 75(4): 231–233.
PMCID: PMC1437655

Saline flush: a simple method of reducing diazepam-induced thrombophlebitis.

Abstract

Five hundred outpatients undergoing endoscopy were admitted into a controlled trial comparing the incidence of thrombophlebitis following intravenous diazepam administered in the way, with the effects of either a saline flush following the diazepam or diluting the drug with the patient's own blood before injection ('barbotage'). The results were assessed using a questionnaire completed by patients two weeks after endoscopy; 80% replied. A saline flush reduced the incidence of side effects, particularly pain (P less than 0.05). 'Barbotage' gave the highest incidence of side effects. Saline flush is therefore recommended as a means of reducing the thrombophlebitis which may follow intravenous diazepam.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (406K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Driscoll EJ, Gelfman SS, Sweet JB, Butler DP, Wirdzck PR, Medlin T. Thrombophlebitis after intravenous use of anesthesia and sedation: its incidence and natural history. J Oral Surg. 1979 Nov;37(11):809–815. [PubMed]
  • Jusko WJ, Gretch M, Gassett R. Precipitation of diazepam from intravenous preparations. JAMA. 1973 Jul 9;225(2):176–176. [PubMed]
  • Langdon DE, Harlan JR, Bailey RL. Thrombophlebitis with diazepam used intravenously. JAMA. 1973 Jan 8;223(2):184–185. [PubMed]
  • Schou Olesen A, Hüttel MS. Local reactions to i.v. diazepam in three different formulations. Br J Anaesth. 1980 Jun;52(6):609–611. [PubMed]
  • von Dardel O, Mebius C, Mossberg T. Diazepam in emulsion form for intravenous usage. Acta Anaesthesiol Scand. 1976;20(3):221–224. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press