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J R Soc Med. 1980 June; 73(6): 431–436.
PMCID: PMC1437605

Neuropharmacological agents modifying endotoxin-induced changes in mice1


A variety of neuropharmacological agents were tested to elucidate how chlorpromazine influenced an endotoxin-induced reaction. The results obtained, particularly with beta-adrenergic blocking agents, reserpine and fusaric acid, suggested that the primary locus of chlorpromazine's action was mediated by peripheral beta-adrenergic receptor blockade. Such a locus is compatible with the low doses of propranolol which suppress the reaction, and with successful treatment of shock with dopamine.

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Selected References

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