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J R Soc Med. 1980 May; 73(5): 345–347.
PMCID: PMC1437479

Effects of phenoxybenzamine on bladder neck opening1


A study of the effects of the action of phenoxybenzamine on bladder neck opening during micturition is reported. Twenty patients with symptoms of prostatism but minimal prostatic enlargement were studied. Bladder neck opening was measured radiographically. Phenoxybenzamine was shown to increase bladder neck opening by an average of 30% and give symptomatic relief. Minimal side effects were noted.

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Selected References

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  • Caine M, Raz S, Zeigler M. Adrenergic and cholinergic receptors in the human prostate, prostatic capsule and bladder neck. Br J Urol. 1975 Apr;47(2):193–202. [PubMed]
  • Dixon JS, Gosling JA. Light and electron microscopic observations on noradrenergic nerves and striated muscle cells of the guinea pig urethra. Am J Anat. 1977 May;149(1):121–126. [PubMed]
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  • Mobley DF. Phenoxybenzamine in the management of neurogenic vesical dysfunction. J Urol. 1976 Dec;116(6):737–738. [PubMed]
  • Nergårdh A, Boréus LO. Autonomic receptor function in the lower urinary tract of man and cat. Scand J Urol Nephrol. 1972;6(1):32–36. [PubMed]

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