PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1980 April; 73(4): 244–254.
PMCID: PMC1437434

Cerebrospinal fluid rhinorrhoea in pituitary tumours1

Abstract

Three cases of CSF rhinorrhoea due to pituitary tumours are reported and the literature reviewed. The treatment of choice appears to be trans-sphenoidal exploration of the pituitary fossa with insertion of a free muscle graft followed by radiotherapy. The probability of the tumour being a prolactin-secreting adenoma is discussed.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.5M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Adson AW. CEREBROSPINAL RHINORRHEA: SURGICAL REPAIR OF CRANIOSINUS FISTULA. Ann Surg. 1941 Oct;114(4):697–705. [PubMed]
  • ANDERSON WM, SCHWARZ GA, GAMMON GD. Chronic spontaneous cerebrospinal rhinorrhea. Arch Intern Med. 1961 May;107:723–731. [PubMed]
  • Bateman GH. Experiences with cerebrospinal fluid rhinorrhoea arising from the pituitary fossa. Proc R Soc Med. 1966 Feb;59(2):169–174. [PMC free article] [PubMed]
  • BEAUCHAMP LE, BENJAMIN B. Cerebrospinal fluid rhinorrhoea and recurrent purulent meningitis. Can Med Assoc J. 1951 Oct;65(4):372–375. [PMC free article] [PubMed]
  • Bergh T, Nillius SJ, Wide L. Hyperprolactinaemic amenorrhoea--results of treatment with bromocriptine. Acta Endocrinol Suppl (Copenh) 1978;216:147–164. [PubMed]
  • Bergland RM, Ray BS, Torack RM. Anatomical variations in the pituitary gland and adjacent structures in 225 human autopsy cases. J Neurosurg. 1968 Feb;28(2):93–99. [PubMed]
  • Bracewell A. Glucose oxidase test strips in the detection of C.S.F. fistula. J Laryngol Otol. 1965 Nov;79(11):1001–1004. [PubMed]
  • Briant TD, Snell D. Diagnosis of cerebro-spinal rhinorrhea and the rhinologic approach to its repair. Laryngoscope. 1967 Aug;77(8):1390–1409. [PubMed]
  • Brisman R, Hughes JE, Mount LA. Cerebrospinal fluid rhinorrhea and the empty sella. J Neurosurg. 1969 Nov;31(5):538–543. [PubMed]
  • BUSCH W. Die Morphologie der Sella turcica und ihre Beziehungen zur Hypophyse. Virchows Arch. 1951 Sep;320(5):437–458. [PubMed]
  • Child DF, Nader S, Mashiter K, Kjeld M, Banks L, Fraser TR. Prolactin studies in "functionless" pituitary tumours. Br Med J. 1975 Mar 15;1(5958):604–606. [PMC free article] [PubMed]
  • Coleman CC, Troland CE. The Surgical Treatment of Spontaneous Cerebrospinal Rhinorrhea. Ann Surg. 1947 Jun;125(6):718–727. [PubMed]
  • CROW HJ, KEOGH C, NORTHFIELD DW. The localisation of cerebrospinal-fluid fistulae. Lancet. 1956 Aug 18;271(6938):325–327. [PubMed]
  • DAVIES RE. A case of recurrent meningitis with cerebrospinal fluid rhinorrhoea. Med J Aust. 1963 Jun 22;50(1):931–932. [PubMed]
  • Di Chiro G, Grove AS., Jr Evaluation of surgical and spontaneous cerebrospinal fluid shunts by isotope scanning. J Neurosurg. 1966 Apr;24(4):743–748. [PubMed]
  • Floyd HL, Pribram HF, Velo AG. Primary cerebrospinal fluid fistula. Am J Roentgenol Radium Ther Nucl Med. 1970 Sep;110(1):88–91. [PubMed]
  • FORBES AP, HENNEMAN PH, GRISWOLD GC, ALBRIGHT F. Syndrome characterized by galactorrhea, amenorrhea and low urinary FSH: comparison with acromegaly and normal lactation. J Clin Endocrinol Metab. 1954 Mar;14(3):265–271. [PubMed]
  • Franks S, Jacobs HS, Hull MG, Steele SJ, Nabarro JD. Management of hyperprolactinaemic amenorrhoea. Br J Obstet Gynaecol. 1977 Apr;84(4):241–253. [PubMed]
  • Franks S, Jacobs HS, Martin N, Nabarro JD. Hyperprolactinaemia and impotence. Clin Endocrinol (Oxf) 1978 Apr;8(4):277–287. [PubMed]
  • Franks S, Jacobs HS, Nabarro JD. Prolactin concentrations in patients with acromegaly: clinical significance and response to surgery. Clin Endocrinol (Oxf) 1976 Jan;5(1):63–69. [PubMed]
  • Franks S, Nabarro JD. Prevalence and presentation of hyperprolactinaemia in patients with "functionless" pituitary tumours. Lancet. 1977 Apr 9;1(8015):778–780. [PubMed]
  • Hwang P, Guyda H, Friesen H. A radioimmunoassay for human prolactin. Proc Natl Acad Sci U S A. 1971 Aug;68(8):1902–1906. [PubMed]
  • GOTHAM JE, MEYER JS, GILROY J, BAUER RB. OBSERVATIONS ON CEREBROSPINAL FLUID RHINORRHEA AND PNEUMOCEPHALUS. Ann Otol Rhinol Laryngol. 1965 Mar;74:215–233. [PubMed]
  • HARPMAN JA. On non-traumatic cerebrospinal fluid rhinorrhoea with recurrent meningitis. J Laryngol Otol. 1957 May;71(5):321–330. [PubMed]
  • Hingorani RK. Cerebrospinal fluid rhinorrhoea. J Laryngol Otol. 1971 Oct;85(10):999–1006. [PubMed]
  • Hosain F, Som P. Chelated 111 In: an ideal radiopharmaceutical for cisternography. Br J Radiol. 1972 Sep;45(537):677–679. [PubMed]
  • Jacobs HS, Franks S, Murray MA, Hull MG, Steele SJ, Nabarro JD. Clinical and endocrine features of hyperprolactinaemic amenorrhoea. Clin Endocrinol (Oxf) 1976 Sep;5(5):439–454. [PubMed]
  • Jacobs HS, Wright CS. Bromocriptine in obstetrics and gynaecology. Br J Hosp Med. 1978 Dec;20(6):652–660. [PubMed]
  • Jacobson I, Maran AG. Localization of cerebrospinal fluid rhinorrhea. Arch Otolaryngol. 1971 Jan;93(1):79–80. [PubMed]
  • Jefferson G. Extrasellar Extensions of Pituitary Adenomas: (Section of Neurology). Proc R Soc Med. 1940 May;33(7):433–458. [PMC free article] [PubMed]
  • JUNGMANN A, PEYSER E. Roentgen visualization fo cerebrospinal fluid fistula with contrast medium. Radiology. 1963 Jan;80:92–95. [PubMed]
  • KAHN A., Jr Spontaneous cerebrospinal rhinorrhea with remission following dye injection. J Am Med Assoc. 1951 Jun 23;146(8):728–729. [PubMed]
  • KAY S, LEES JK, STOUT AP. Pituitary chromophobe tumors of the nasal cavity. Cancer. 1950 Jul;3(4):695–704. [PubMed]
  • KIRCHNER FR, PROUD GO. Method for the identification and localization of cerebrospinal fluid, rhinorrhea and otorrhea. Laryngoscope. 1960 Jul;70:921–931. [PubMed]
  • Kirsch AP. Diagnosis of cerebrospinal fluid rhinorrhea: lack of specificity of the glucose oxidase test tape. J Pediatr. 1967 Nov;71(5):718–719. [PubMed]
  • KLEINFELD M, AXELROD M, COHEN A. Recurrent meningitis and cerebrospinal rhinorrhea. N Y State J Med. 1950 May 15;50(10):1244–1246. [PubMed]
  • Lewis UJ, Singh RN, Sinha YN, VanderLaan WP. Electrophoretic evidence for human prolactin. J Clin Endocrinol Metab. 1971 Jul;33(1):153–156. [PubMed]
  • LIST CF. Management of chromophobe pituitary adenoma. Neurology. 1953 Nov;3(11):825–830. [PubMed]
  • Clinical Memoranda. Br Med J. 1938 Jun 4;1(4039):1208–1209. [PMC free article] [PubMed]
  • LOVE JG, WHITE RJ. Cerebrospinal rhinorrhea associated with tumor of the fourth ventricle. Report of a case. J Neurosurg. 1960 Nov;17:1083–1088. [PubMed]
  • MORLEY TP, HETHERINGTON RF. Traumatic cerebrospinal fluid rhinorrhea and otorrhea, pneumocephalus, and meningitis. Surg Gynecol Obstet. 1957 Jan;104(1):88–98. [PubMed]
  • Morris L, Wylie I. Radiological assessment of the pituitary gland. Acta Neurochir (Wien) 1974;Suppl 21:151–158. [PubMed]
  • Nair S, Nair K, Roberts M. Non-traumatic cerebrospinal fluid rhinorrhea with lung abscess: report of a case and review of literature. Conn Med. 1973 Dec;37(12):611–615. [PubMed]
  • NORI A, CARTERI A. RINOLIQUORREA: TRATTAMENTO E RISULTATI A DISTANZA. Chir Ital. 1964 Feb;16:161–165. [PubMed]
  • NORSA L. Cerebrospinal rhinorrhea with pituitary tumors. Neurology. 1953 Nov;3(11):864–868. [PubMed]
  • Nussey AM. Spontaneous cerebrospinal-fluid rhinorrhoea. Br Med J. 1966 Jun 25;1(5503):1579–1580. [PMC free article] [PubMed]
  • O'CONNELL JE. PRIMARY SPONTANEOUS CEREBROSPINAL FLUID RHINORRHOEA. J Neurol Neurosurg Psychiatry. 1964 Jun;27:241–246. [PMC free article] [PubMed]
  • OLDBERG E. Cerebrospinal fluid rhinorrhea. Postgrad Med. 1954 Jul;16(1):1–5. [PubMed]
  • Olson DR, Guiot G, Derome P. The symptomatic empty sella. Prevention and correction via the transsphenoidal approach. J Neurosurg. 1972 Nov;37(5):533–537. [PubMed]
  • Ommaya AK, Di Chiro G, Baldwin M, Pennybacker JB. Non-traumatic cerebrospinal fluid rhinorrhoea. J Neurol Neurosurg Psychiatry. 1968 Jun;31(3):214–225. [PMC free article] [PubMed]
  • Plunkett JE, Lendrum FC. A Case of Spontaneous Pneumocephalus and Cerebrospinal Rhinorrhoea. Can Med Assoc J. 1935 Nov;33(5):512–514. [PMC free article] [PubMed]
  • RAND RW. Spontaneous cerebrospinal rhinorrhea. Bull Los Angel Neuro Soc. 1953 Jun;18(2):74–83. [PubMed]
  • RASKIND R. CEREBROSPINAL FLUID RHINORRHEA AND OTORRHEA. DIAGNOSIS AND TREATMENT IN 35 CASES. J Int Coll Surg. 1965 Feb;43:141–154. [PubMed]
  • Schechter MM, Rovit RL, Nelson K. Spontaneous "high pressure CSF rhinorrhoea". Cerebrospinal fluid leakage caused by long-standing increased intracranial pressure. Br J Radiol. 1969 Aug;42(500):619–622. [PubMed]
  • SHELINE GE, BOLDREY EB, PHILLIPS TL. CHROMOPHOBE ADENOMAS OF THE PITUITARY GLAND. Am J Roentgenol Radium Ther Nucl Med. 1964 Jul;92:160–173. [PubMed]
  • TENG P, EDALATPOUR N. CERBROSPINAL FLUID RHINORRHEA WITH DEMONSTRATION OF CRANIO-NASAL FISTULA WITH PANTOPAQUE. Radiology. 1963 Nov;81:802–806. [PubMed]
  • TENG P, PAPATHEODOROU C. CEREBROSPINAL RHINORRHEA AND OTORRHEA; RADIOGRAPHIC DIAGNOSIS AND SURGICAL TREATMENT. Arch Otolaryngol. 1965 Jul;82:56–61. [PubMed]
  • Thorner MO, McNeilly AS, Hagan C, Besser GM. Long-term treatment of galactorrhoea and hypogonadism with bromocriptine. Br Med J. 1974 May 25;2(5916):419–422. [PMC free article] [PubMed]
  • TROLAND CE. The surgical treatment of spontaneous cerebrospinal rhinorrhea. Arch Otolaryngol. 1960 Aug;72:254–255. [PubMed]
  • VRABEC DP, HALLBERG OE. CEREBROSPINAL FLUID RHINORRHEA. INTRANASAL APPROACH, REVIEW OF THE LITERATURE, AND REPORT OF A CASE. Arch Otolaryngol. 1964 Aug;80:218–229. [PubMed]
  • Weiss MH, Kaufman B, Richards DE. Cerebrospinal fluid rhinorrhea from an empty sella: transsphenoidal obliteration of the fistula. Technical note. J Neurosurg. 1973 Nov;39(5):674–676. [PubMed]
  • Williams RA. Transsphenoid hypophysectomy for acromegaly. Proc R Soc Med. 1974 Sep;67(9):881–885. [PMC free article] [PubMed]
  • WILLIAMSON WP, BARELLI PA. Intranasal encephalocele. J Neurosurg. 1951 Mar;8(2):231–235. [PubMed]
  • YOUNGS NA, PEYTON W. Spontaneous cerebrospinal rhinorrhea secondary to the Arnold-Chiari malformation. Laryngoscope. 1953 Mar;63(3):241–248. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press