PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1982 February; 75(2): 102–106.
PMCID: PMC1437265

Thyroid dysfunction and rheumatic diseases.

Abstract

Musculoskeletal symptoms developing during the treatment of thyroid disease were studied in 150 patients; 17 developed a symptom complex of early morning stiffness together with shoulder girdle pain and weakness; similar symptoms were seen in only 3 of 100 controls. A prospective study of 16 patients with recent onset rheumatoid arthritis followed during the first 6 months of penicillamine therapy showed no changes in thyroid function tests. It is suggested that changing or abnormal thyroid status may precipitate or exacerbate musculoskeletal disease. Finally, in a retrospective study of 26 patients with both thyroid disease and rheumatoid arthritis, 4 patients had a simultaneous onset of both myxoedema and rheumatoid arthritis, the activity of which was greatly improved by correction of the hypothyroid state.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (607K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • BECKER KL, FERGUSON RH, McCONAHEY WM. The connective-tissue diseases and symptoms associated with Hashimoto's thyroiditis. N Engl J Med. 1963 Feb 7;268:277–280. [PubMed]
  • Bird HA, Esselinckx W, Dixon AS, Mowat AG, Wood PH. An evaluation of criteria for polymyalgia rheumatica. Ann Rheum Dis. 1979 Oct;38(5):434–439. [PMC free article] [PubMed]
  • Bland JH, Frymoyer JW. Rheumatic syndromes of myxedema. N Engl J Med. 1970 May 21;282(21):1171–1174. [PubMed]
  • CHAPMAN EM, MALOOF F. Bizarre clinical manifestations of hyperthyroidism. N Engl J Med. 1956 Jan 5;254(1):1–5. [PubMed]
  • Dent RG, Edwards OM. Autoimmune thyroid disease and the polymyalgia rheumatica-giant cell arteritis syndrome. Clin Endocrinol (Oxf) 1978 Sep;9(3):215–219. [PubMed]
  • Golding DN. Hypothyroidism presenting with musculoskeletal symptoms. Ann Rheum Dis. 1970 Jan;29(1):10–14. [PMC free article] [PubMed]
  • How J, Bewsher PD, Walker W. Giant-cell arteritis and hypothyroidism. Br Med J. 1977 Jul 9;2(6079):99–99. [PMC free article] [PubMed]
  • LAINE VA, VAINIO KJ, HOLOPAINEN TE. Effect of thyroidectomy in rheumatoid arthritis. Ann Rheum Dis. 1954 Sep;13(3):250–251. [PMC free article] [PubMed]
  • Norris FH, Jr, Panner BJ. Hypothyroid myopathy. Clinical, electromyographical, and ultrastructural observations. Arch Neurol. 1966 Jun;14(6):574–589. [PubMed]
  • Ramsay ID. Muscle dysfunction in hyperthyroidism. Lancet. 1966 Oct 29;2(7470):931–934. [PubMed]
  • Ritchie DM, Boyle JA, McInnes JM, Jasani MK, Dalakos TG, Grieveson P, Buchanan WW. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968 Jul;37(147):393–406. [PubMed]
  • ROPES MW, BENNETT GA, COBB S, JACOX R, JESSAR RA. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed]
  • Thomas RD, Croft DN. Thyrotoxicosis and giant-cell arteritis. Br Med J. 1974 May 25;2(5916):408–409. [PMC free article] [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press