PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of gutGutView this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
Gut. 1988 September; 29(9): 1173–1179.
PMCID: PMC1434376

Colonic mass movements in idiopathic chronic constipation.

Abstract

As relatively little is known of human colonic motor activity either in health, or in pathological conditions, we investigated mass movements in 14 chronically constipated patients and 18 healthy volunteers. Mass movements were recorded from proximal and distal colon during 24 h (12 noon-12 noon) by a colonoscopically positioned multilumen manometric probe and low compliance infusion system. Patients and controls differed significantly in the number (mean 2.6 (0.7) v 6.1 (0.9) (SE), p = 0.02) and duration (mean 8.2 (1.6) v 14.1 (0.8) s, p = 0.04) of mass movements. The data suggest that one pathophysiological mechanism of constipation may be decreased propulsive activity. A circadian pattern, with a significant difference between day and night distribution, was documented in both groups. The patients reported decreased defecatory stimulus concomitant with the mass movements.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bueno L, Fioramonti J, Ruckebusch Y, Frexinos J, Coulom P. Evaluation of colonic myoelectrical activity in health and functional disorders. Gut. 1980 Jun;21(6):480–485. [PMC free article] [PubMed]
  • Lanfranchi GA, Bazzocchi G, Brignola C, Campieri M, Labò G. Different patterns of intestinal transit time and anorectal motility in painful and painless chronic constipation. Gut. 1984 Dec;25(12):1352–1357. [PMC free article] [PubMed]
  • Devroede G. La constipation: du symptôme vers la personne. Gastroenterol Clin Biol. 1985 Jan;9(1):3–6. [PubMed]
  • Schang JC, Devroede G, Duguay C, Hémond M, Hébert M. Constipation par inertie colique et obstruction distale: étude électromyographique. Gastroenterol Clin Biol. 1985 Jun-Jul;9(6-7):480–485. [PubMed]
  • Reynolds JC, Ouyang A, Lee CA, Baker L, Sunshine AG, Cohen S. Chronic severe constipation. Prospective motility studies in 25 consecutive patients. Gastroenterology. 1987 Feb;92(2):414–420. [PubMed]
  • Meunier P, Rochas A, Lambert R. Motor activity of the sigmoid colon in chronic constipation: comparative study with normal subjects. Gut. 1979 Dec;20(12):1095–1101. [PMC free article] [PubMed]
  • Misiewicz JJ. Colonic motility. Gut. 1975 Apr;16(4):311–314. [PMC free article] [PubMed]
  • Huizinga JD, Daniel EE. Control of human colonic motor function. Dig Dis Sci. 1986 Aug;31(8):865–877. [PubMed]
  • Wingate D. The tunnel at the end of the light. Gut. 1986 Sep;27(9):995–998. [PMC free article] [PubMed]
  • Frexinos J, Bueno L, Fioramonti J. Diurnal changes in myoelectric spiking activity of the human colon. Gastroenterology. 1985 May;88(5 Pt 1):1104–1110. [PubMed]
  • Narducci F, Bassotti G, Gaburri M, Morelli A. Twenty four hour manometric recording of colonic motor activity in healthy man. Gut. 1987 Jan;28(1):17–25. [PMC free article] [PubMed]
  • Bassotti G, Imbimbo BP, Gaburri M, Daniotti S, Morelli A. Transverse and sigmoid colon motility in healthy humans: effects of eating and of cimetropium bromide. Digestion. 1987;37(1):59–64. [PubMed]
  • Wall GM, Kenny JC, Fan TY, Schafer C, Ready MA, Baker JK, Ritter P, Scott BS. Analysis of 3- and 4-monopivaloylepinephrine, degradation products in dipivefrin hydrochloride drug substance and ophthalmic formulations. J Pharm Biomed Anal. 1992 Jun;10(6):465–471. [PubMed]
  • Ritchie J. Mass peristalsis in the human colon after contact with oxyphenisatin. Gut. 1972 Mar;13(3):211–219. [PMC free article] [PubMed]
  • Bassotti G, Gaburri M, Giacomo Clausi G, Pelli MA, Morelli A. Can idiopathic megacolon cause functional motor abnormalities in the upper gastrointestinal tract? Hepatogastroenterology. 1987 Aug;34(4):186–189. [PubMed]
  • Narducci F, Bassotti G, Gaburri M, Morelli A. Transition from nutcracker esophagus to diffuse esophageal spasm. Am J Gastroenterol. 1985 Apr;80(4):242–244. [PubMed]
  • Narducci F, Bassotti G, Granata MT, Gaburri M, Farroni F, Palumbo R, Morelli A. Functional dyspepsia and chronic idiopathic gastric stasis. Role of endogenous opiates. Arch Intern Med. 1986 Apr;146(4):716–720. [PubMed]
  • Sullivan MA, Cohen S, Snape WJ., Jr Colonic myoelectrical activity in irritable-bowel syndrome. Effect of eating and anticholinergics. N Engl J Med. 1978 Apr 20;298(16):878–883. [PubMed]
  • Narducci F, Bassotti G, Daniotti S, Del Soldato P, Pelli MA, Morelli A. Identification of muscarinic receptor subtype mediating colonic response to eating. Dig Dis Sci. 1985 Feb;30(2):124–128. [PubMed]
  • Narducci F, Bassotti G, Granata MT, Pelli MA, Gaburri M, Palumbo R, Morelli A. Colonic motility and gastric emptying in patients with irritable bowel syndrome. Effect of pretreatment with octylonium bromide. Dig Dis Sci. 1986 Mar;31(3):241–246. [PubMed]
  • COCHRAN WG. The comparison of percentages in matched samples. Biometrika. 1950 Dec;37(3-4):256–266. [PubMed]
  • Preston DM, Lennard-Jones JE. Severe chronic constipation of young women: 'idiopathic slow transit constipation'. Gut. 1986 Jan;27(1):41–48. [PMC free article] [PubMed]
  • Watier A, Devroede G, Duranceau A, Abdel-Rahman M, Duguay C, Forand MD, Tétreault L, Arhan P, Lamarche J, Elhilali M. Constipation with colonic inertia. A manifestation of systemic disease? Dig Dis Sci. 1983 Nov;28(11):1025–1033. [PubMed]
  • Frexinos J. Inertie colique primitive: mythe ou réalité? Gastroenterol Clin Biol. 1987 Apr;11(4):302–306. [PubMed]
  • Ritchie JA. Colonic motor activity and bowel function. I. Normal movement of contents. Gut. 1968 Aug;9(4):442–456. [PMC free article] [PubMed]
  • Hardcastle JD, Mann CV. Study of large bowel peristalsis. Gut. 1968 Oct;9(5):512–520. [PMC free article] [PubMed]
  • Holdstock DJ, Misiewicz JJ, Smith T, Rowlands EN. Propulsion (mass movements) in the human colon and its relationship to meals and somatic activity. Gut. 1970 Feb;11(2):91–99. [PMC free article] [PubMed]
  • Kellow JE, Borody TJ, Phillips SF, Tucker RL, Haddad AC. Human interdigestive motility: variations in patterns from esophagus to colon. Gastroenterology. 1986 Aug;91(2):386–395. [PubMed]
  • Kumar D, Wingate D, Ruckebusch Y. Circadian variation in the propagation velocity of the migrating motor complex. Gastroenterology. 1986 Oct;91(4):926–930. [PubMed]
  • Krishnamurthy S, Schuffler MD, Rohrmann CA, Pope CE., 2nd Severe idiopathic constipation is associated with a distinctive abnormality of the colonic myenteric plexus. Gastroenterology. 1985 Jan;88(1 Pt 1):26–34. [PubMed]

Articles from Gut are provided here courtesy of BMJ Publishing Group