PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of gutGutCurrent TOCInstructions to authors
 
Gut. Nov 1988; 29(11): 1564–1568.
PMCID: PMC1433820
Low gluten diet in the treatment of adult coeliac disease: effect on jejunal morphology and serum anti-gluten antibodies.
A M Montgomery, A K Goka, P J Kumar, M J Farthing, and M L Clark
Department of Gastroenterology, St Bartholomew's Hospital, London.
Abstract
Treatment of patients with coeliac disease with a low gluten containing diet (LGD) remains controversial. We have studied jejunal morphology and antigluten (AG) antibody titres by ELISA in patients on a LGD of 2.5-5 g/day for three to 14 months (median six months) and compared results with patients on a strict gluten free diet (GFD) for six to 27 months (median 13 months). We found no significant difference in villous height or crypt depth (eight LGD v 10 GFD patients) or serum AG-IgA, -IgG, and IgM titres (13 LGD v 12 GFD patients). there was however, a significant increase (p less than 0.05) in intra-epithelial lymphocytes in those patients on a LGD. We conclude that adult coeliac patients can tolerate a LGD without gross morphological change and without initiating significant AG antibody responses.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (621K), or click on a page image below to browse page by page.
Articles from Gut are provided here courtesy of
BMJ Group