Search tips
Search criteria 


Logo of gutGutView this articleSubmit a manuscriptReceive email alertsContact usBMJ
Gut. 1979 February; 20(2): 169–175.
PMCID: PMC1419453

Peutz-Jeghers syndrome associated with gastrointestinal carcinoma. Report of two cases in a family.


Patients with the Peutz-Jeghers syndrome carry a slight, though definite, increased risk of gastrointestinal carcinoma. The malignant potentiality of Peutz-Jeghers hamartomatous polyps, generally considered benign, is supported by this report. Two cases of metastasising gastrointestinal carcinoma associated with the Peutz-Jeghers syndrome are described in a 56 year old female and her 29 year old son. Both mother and son died from duodenal and gastric carcinomas respectively, which developed in hamartomatous polyps with extensive metastases. Both cases also showed dysplastic areas within hamartomatous polyps. These features indicate that hamartomatous polyps may, in some cases, be the precursors of digestive tract carcinomas.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (3.6M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Dozois RR, Judd ES, Dahlin DC, Bartholomew LG. The Peutz-Jeghers syndrome. Is there a predisposition to the development of intestinal malignancy? Arch Surg. 1969 Apr;98(4):509–517. [PubMed]
  • BAILEY D. Polyposis of gastro-intestinal tract: the Peutz syndrome. Br Med J. 1957 Aug 24;2(5042):433–439. [PMC free article] [PubMed]
  • BARTHOLOMEW LG, DAHLIN DC, WAUGH JM. Intestinal polyposis associated with mucocutaneous melanin pigmentation Peutz-Jeghers syndrome; review of literature and report of six cases with special reference to pathologic findings. Gastroenterology. 1957 Mar;32(3):434–451. [PubMed]
  • Bussey HJ. Gastrointestinal polyposis. Gut. 1970 Nov;11(11):970–978. [PMC free article] [PubMed]
  • Dodds WJ, Schulte WJ, Hensley GT, Hogan WJ. Peutz-Jeghers syndrome and gastrointestinal malignancy. Am J Roentgenol Radium Ther Nucl Med. 1972 Jun;115(2):374–377. [PubMed]
  • DORMANDY TL. Gastrointestinal polyposis with mucocutaneous pigmentation (Peutz-Jeghers syndrome). N Engl J Med. 1957 Jun 13;256(24):1141–contd. [PubMed]
  • Dozois RR, Judd ES, Dahlin DC, Bartholomew LG. The Peutz-Jeghers syndrome. Is there a predisposition to the development of intestinal malignancy? Arch Surg. 1969 Apr;98(4):509–517. [PubMed]
  • HORN RC, Jr, PAYNE WA, FINE G. The Peutz-Jeghers syndrome. (Gastrointestinal polyposis with mucocutaneous pigmentation): report of a case terminating with disseminated gastrointestinal cancer. Arch Pathol. 1963 Jul;76:29–37. [PubMed]
  • JEGHERS H, McKUSICK VA, KATZ KH. Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance. N Engl J Med. 1949 Dec 29;241(26):1031–1036. [PubMed]
  • MEGEVAND A. Polypose viscérale et pigmentation mélanique cutanéo-muqueuse (syndrome de Peutz). Arch Fr Pediatr. 1959;16(3):353–361. [PubMed]
  • Payson BA, Moumgis B. Metastasizing carcinoma of the stomach in Peutz-Jeghers syndrome. Ann Surg. 1967 Jan;165(1):145–151. [PubMed]
  • Reid JD. Intestinal carcinoma in the Peutz-Jeghers syndrome. JAMA. 1974 Aug 12;229(7):833–834. [PubMed]
  • RINTALA A. The histological appearance of gastrointestinal polyps in the Peutz-Jeghers syndrome. Acta Chir Scand. 1959 Sep 20;117:366–373. [PubMed]
  • Shibata HR, Phillips MJ. Peutz-Jeghers syndrome with jejunal and colonic adenocarcinomas. Can Med Assoc J. 1970 Aug 1;103(3):285–287. [PMC free article] [PubMed]
  • Warren KW, Kune GA, Poulantzas JK. Peutzjeghers syndrome with carcinoma of the duodenum and jejunum. Lahey Clin Found Bull. 1965;14(3):97–102. [PubMed]
  • Wennstrom J, Pierce ER, McKusick VA. Hereditary benign and malignant lesions of the large bowel. Cancer. 1974 Sep;34(3):suppl–suppl:857. [PubMed]

Articles from Gut are provided here courtesy of BMJ Group