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Br Med J (Clin Res Ed). 1985 February 2; 290(6465): 345–347.
PMCID: PMC1417374

Results of surgical treatment for extrahepatic biliary atresia in United Kingdom 1980-2. Survey conducted on behalf of the British Paediatric Association Gastroenterology Group and the British Association of Paediatric Surgeons.


A postal survey identified 114 infants with biliary atresia (roughly one in 21 000 live births). Biliary operations were performed on 107. Of the 105 infants who were followed up, 35 were free of jaundice at 10 months to 3 1/2 years. Good results occurred most often in those operated on by 12 weeks and were also related to the number of cases operated on in each centre. Only two of 18 infants treated in centres dealing with one case a year were free of jaundice compared with 11 of 38 at centres treating two to five cases a year and 22 of 49 in a centre treating more than five cases a year. Jaundice in an infant of more than 2 weeks associated with yellow urine or pale stools is never physiological and requires urgent investigation to identify causes for which effective treatment may be possible. Identification of suspected cases by 4 weeks of age and a greater concentration of investigative and surgical skills should improve the short term results of surgery and the long term prognosis of biliary atresia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Adelman S. Prognosis of uncorrected biliary atresia: an update. J Pediatr Surg. 1978 Aug;13(4):389–391. [PubMed]
  • Mowat AP, Psacharopoulos HT, Williams R. Extrahepatic biliary atresia versus neonatal hepatitis. Review of 137 prospectively investigated infants. Arch Dis Child. 1976 Oct;51(10):763–770. [PMC free article] [PubMed]
  • Kasai M. Advances in treatment of biliary atresia. Jpn J Surg. 1983 Jul;13(4):265–276. [PubMed]
  • Howard ER, Driver M, McClement J, Mowat AP. Results of surgery in 88 consecutive cases of extrahepatic biliary atresia. J R Soc Med. 1982 Jun;75(6):408–413. [PubMed]
  • Zawada ET, Jr, Johnston WH, Bergstein J. Chronic interstitial nephritis. Its occurrence with oxalosis and anti-tubular basement membrane antibodies after jejunoileal bypass. Arch Pathol Lab Med. 1981 Jul;105(7):379–383. [PubMed]
  • Markowitz J, Daum F, Kahn EI, Schneider KM, So HB, Altman RP, Aiges HW, Alperstein G, Silverberg M. Arteriohepatic dysplasia. I. Pitfalls in diagnosis and management. Hepatology. 1983 Jan-Feb;3(1):74–76. [PubMed]

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