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Gut. 1979 September; 20(9): 811–814.
PMCID: PMC1412643

Achalasia and diffuse oesophageal spasm in siblings.


We report the occurrence of achalasia and diffuse oesophageal spasm in brother and sister. The familial occurrence of these unusual disorders is consistent with the possibility that they share a common aetiology and indicates the potential importance of genetic predisposition.

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Selected References

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  • Binder HJ, Bloom DL, Stern H, Solitare GB, Thayer WR, Spiro HM. The effect of cervical vagectomy on esophageal function in the monkey. Surgery. 1968 Dec;64(6):1075–1083. [PubMed]
  • Kramer P, Fleshler B, McNally E, Harris LD. Oesophageal sensitivity to Mecholyl in symptomatic diffuse spasm. Gut. 1967 Apr;8(2):120–127. [PMC free article] [PubMed]
  • Kramer P, Harris LD, Donaldson RM., Jr Transition from symptomatic diffuse spasm to cardiospasm. Gut. 1967 Apr;8(2):115–119. [PMC free article] [PubMed]
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