PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of brjgenpracRCGP homepageJ R Coll Gen Pract at PubMed CentralBJGP at RCGPBJGP at RCGP
 
Br J Gen Pract. 1997 December; 47(425): 827–828.
PMCID: PMC1410066

Adrenaline degradation in general practice.

Abstract

The general practitioner's (GP's) doctor's bag is exposed to extreme temperatures that may affect the stability of the drugs it contains. Adrenaline (1:1000 solution) is more stable than previous studies would suggest. GPs carry out-of-date drugs despite stating that they regularly check expiry dates.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (381K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
 
 

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Avery A, Pringle M. Emergency care in general practice. BMJ. 1995 Jan 7;310(6971):6–6. [PMC free article] [PubMed]
  • Rudland SV, Jacobs AG. Visiting bags: a labile thermal environment. BMJ. 1994 Apr 9;308(6934):954–956. [PMC free article] [PubMed]
  • Grant TA, Carroll RG, Church WH, Henry A, Prasad NH, Abdel-Rahman AA, Allison EJ., Jr Environmental temperature variations cause degradations in epinephrine concentration and biological activity. Am J Emerg Med. 1994 May;12(3):319–322. [PubMed]
  • Church WH, Hu SS, Henry AJ. Thermal degradation of injectable epinephrine. Am J Emerg Med. 1994 May;12(3):306–309. [PubMed]
  • Kelly JR, Dalm GW. Stability of epinephrine in dental anesthetic solutions: implications for autoclave sterilization and elevated temperature storage. Mil Med. 1985 Feb;150(2):112–114. [PubMed]
  • Fry BW, Ciarlone AE. Concentrations of vasoconstrictors in local anesthetics change during storage in cartridge heaters. J Dent Res. 1980 Jul;59(7):1163–1163. [PubMed]
  • Fry BW, Ciarlone AE. Storage at body temperature alters concentration of vasoconstrictors in local anesthetics. J Dent Res. 1980 Jun;59(6):1069–1069. [PubMed]
  • Goldstein DS. Modified sample preparation for high-performance liquid chromatographic--electrochemical assay of urinary catecholamines. J Chromatogr. 1983 Jun 10;275(1):174–177. [PubMed]
  • Rump AF, Klaus W. Functional effects of adrenochrome in isolated rabbit heart. Pharmacol Toxicol. 1995 Aug;77(2):102–105. [PubMed]

Articles from The British Journal of General Practice are provided here courtesy of Royal College of General Practitioners