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Gut. 1992 July; 33(7): 938–941.
PMCID: PMC1379408

Benign and malignant colorectal strictures in ulcerative colitis.

Abstract

Colorectal strictures, either benign or malignant, are not uncommon in ulcerative colitis. Fifty nine of 1156 ulcerative colitis patients (5%) admitted to this hospital between 1959 and 1983 developed 70 separate colorectal strictures. Seventeen of the 70 strictures (24%) proved to be malignant and the other 53 benign. Nine patients developed more than one stricture. Three principal features distinguished the 17 malignant from the 53 benign strictures in this series: (1) appearance late in the course of ulcerative colitis (61% probability of malignancy in strictures that develop after 20 years of disease v 0% probability in those occurring before 10 years); (2) location proximal to the splenic flexure (86% probability of malignancy v 47% in sigmoid, 10% in rectum, and 0% in splenic flexure and descending colon); and (3) symptomatic large bowel obstruction (100% probability of malignancy v only 14% in the absence of obstruction or constipation). Moreover, cancer associated with strictures tends to be more advanced (76% stage D, 24% A and B) than that which does not produce strictures (18% stage D, 59% A and B).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • ASTLER VB, COLLER FA. The prognostic significance of direct extension of carcinoma of the colon and rectum. Ann Surg. 1954 Jun;139(6):846–852. [PubMed]
  • De Dombal FT, Watts JM, Watkinson G, Goligher JC. Local complications of ulcerative colitis: stricture, pseudopolyposis, and carcinoma of colon and rectum. Br Med J. 1966 Jun 11;1(5501):1442–1447. [PMC free article] [PubMed]
  • EDWARDS FC, TRUELOVE SC. THE COURSE AND PROGNOSIS OF ULCERATIVE COLITIS. III. COMPLICATIONS. Gut. 1964 Feb;5:1–22. [PMC free article] [PubMed]
  • Lashner BA, Turner BC, Bostwick DG, Frank PH, Hanauer SB. Dysplasia and cancer complicating strictures in ulcerative colitis. Dig Dis Sci. 1990 Mar;35(3):349–352. [PubMed]
  • Goldberg HI, Caruthers SB, Jr, Nelson JA, Singleton JW. Radiographic findings of the National Cooperative Crohn's Disease Study. Gastroenterology. 1979 Oct;77(4 Pt 2):925–937. [PubMed]
  • LUMB G, PROTHEROE RH. Ulcerative colitis; a pathologic study of 152 surgical specimens. Gastroenterology. 1958 Mar;34(3):381–407. [PubMed]
  • LUMB G. Pathology of ulcerative colitis. Gastroenterology. 1961 Feb;40:290–298. [PubMed]
  • Goulston SJ, McGovern VJ. The nature of benign strictures in ulcerative colitis. N Engl J Med. 1969 Aug 7;281(6):290–295. [PubMed]
  • KIRSNER JB, PALMER WL, KLOTZ A. Reversibility in ulcerative colitis; clinical and roentgenologic observations. Radiology. 1951 Jul;57(1):1–14. [PubMed]
  • Hunt RH, Teague RH, Swarbrick ET, Williams CB. Colonoscopy in management of colonic strictures. Br Med J. 1975 Aug 9;3(5979):360–361. [PMC free article] [PubMed]
  • Greenstein AJ, Sachar DB, Smith H, Pucillo A, Papatestas AE, Kreel I, Geller SA, Janowitz HD, Aufses AH., Jr Cancer in universal and left-sided ulcerative colitis: factors determining risk. Gastroenterology. 1979 Aug;77(2):290–294. [PubMed]

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